Evidence map›Paper›PMID 29051279›Full record

ArticleHaematologica2018

Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models.

Jieyu Wang, Yoshihiro Hayashi, Asumi Yokota, Zefeng Xu, Yue Zhang, Rui Huang, Xiaomei Yan, Hongyun Liu, Liping Ma, Mohammad Azam and 6 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Insights from the use of erythropoietin in experimental Chagas disease.International journal for parasitology. Drugs and drug resistance · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Erythrocytosis: genes and pathways involved in disease development.Blood transfusion = Trasfusione del sangue · 2021
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Identification and Functional Analysis of EPORJournal of immunology research · 2020
    Article
  16. JACC. Basic to translational science · 2019
    Article
  17. Article
  18. Article
  19. Review
  20. Clonal Hematopoiesis and Its Impact on Cardiovascular Disease.Circulation journal : official journal of the Japanese Circulation Society · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Jieyu WangDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH, USA.
Yoshihiro HayashiDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH, USA.
Asumi YokotaDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH, USA.
Zefeng XuDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH, USA.
Yue ZhangDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH, USA.
Rui HuangDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH, USA.
Xiaomei YanDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH, USA.
Hongyun LiuYat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Liping MaYat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Mohammad AzamDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH, USA.
James P BridgesDivision of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, OH, USA.
Jose A CancelasDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH, USA.
Theodosia A KalfaCancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, OH, USA.
Xiuli AnLaboratory of Membrane Biology, New York Blood Center, New York, NY, USA.
Zhijian XiaoState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Gang HuangDivisions of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, OH, USA gang.huang@cchmc.org.
Cincinnati Children's Hospital Medical Center · USChinese Academy of Medical Sciences & Peking Union Medical College · CNInstitute of Hematology & Blood Diseases Hospital · CNNew York Blood Center · USSun Yat-sen Memorial Hospital · CNSun Yat-sen University · CN

Funding

Role of the Hypoxia-Inducible Factor-1alpha in Myelodysplastic SyndromesR01DK105014 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HUANG, GANG · 2015 to 2019
$1.8M
Improved therapeutic approaches for hematological disorder treated with tyrosineR01CA155091 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI AZAM, MOHAMMAD · 2012 to 2016
$1.6M
NCI NIH HHS R01 CA155091NIDDK NIH HHS R01 DK105014
6 · The paper itself

Abstract

Activated erythropoietin (EPO) receptor (EPOR) signaling causes erythrocytosis. The important role of macrophages for the erythroid expansion and differentiation process has been reported, both in baseline and stress erythropoiesis. However, the significance of EPOR signaling for regulation of macrophages contributing to erythropoiesis has not been fully understood. Here we show that EPOR signaling activation quickly expands both erythrocytes and macrophages

Indexed as

Signal TransductionAnimalsBiomarkersCell CountCytokine Receptor Common beta SubunitCytokinesDisease Models, AnimalErythroblastsErythropoietinGene Expression RegulationGene OrderGenes, ReporterGenetic VectorsInflammation MediatorsMacrophagesMiceBiomarkersCytokine Receptor Common beta SubunitCytokinesErythropoietinInflammation Mediatorsinnate repair receptorReceptors, Erythropoietin

Identifiers

PMID29051279
PMCPMC5777189
OpenAlexW2766718007

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.