Trial reportThe European respiratory journal2017
Effect of morphine on breathlessness and exercise endurance in advanced COPD: a randomised crossover trial.
Trial report in The European respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Opioids for the palliation of symptoms in people with serious respiratory illness: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Fixed-intensity exercise tests to measure exertional dyspnoea in chronic heart and lung populations: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Opioid Prescription Method for Breathlessness Due to Non-Cancer Chronic Respiratory Diseases: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- High-Flow Nasal Cannula Therapy for Exertional Dyspnea in Patients with Cancer: A Pilot Randomized Clinical Trial.The oncologist · 2021Trial
- Effect of l-menthol on breathlessness and exercise endurance in COPD: a randomised crossover trial.ERJ open research · 2026Article
- Effect of fan-to-face therapy on exertional breathlessness in adults with chronic lung disease.ERJ open research · 2026Article
- High Throughput Pharmacovigilance Screening for Roflumilast Adverse Effects in Real-World Settings: A Sequence Symmetry Analysis.Basic & clinical pharmacology & toxicology · 2025Article
- Management of Refractory Chronic Obstructive Pulmonary Disease: A Review.Life (Basel, Switzerland) · 2024Review
- Opioids in Treatment of Refractory Dyspnea in Chronic Obstructive Pulmonary Disease: Yes, No or Maybe.Journal of personalized medicine · 2024Review
- Lung Hyperinflation as Treatable Trait in Chronic Obstructive Pulmonary Disease: A Narrative Review.International journal of chronic obstructive pulmonary disease · 2024Review
- Abnormally high exertional breathlessness predicts mortality in people referred for incremental cycle exercise testing.PloS one · 2024Article
- Caring for patients with advanced COPD: beyond the inhalers….Breathe (Sheffield, England) · 2023Review
- Reference equations for breathlessness during incremental cycle exercise testing.ERJ open research · 2023Article
- Opioids in patients with COPD and refractory dyspnea: literature review and design of a multicenter double blind study of low dosed morphine and fentanyl (MoreFoRCOPD).BMC pulmonary medicine · 2021Review
- Benefits, for patients with late stage chronic obstructive pulmonary disease, of being cared for in specialized palliative care compared to hospital. A nationwide register study.BMC palliative care · 2021Article
- How to Assess Breathlessness in Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2021Review
- Article
- Use of short-acting opioids in the management of breathlessness: an evidence-based review.Current opinion in supportive and palliative care · 2020Review
- Pandemic palliative care: beyond ventilators and saving lives.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Review
- Dyspnea in COPD: New Mechanistic Insights and Management Implications.Advances in therapy · 2020Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The objective of the present study was to evaluate the effect of morphine on exertional breathlessness and exercise endurance in advanced chronic obstructive pulmonary disease (COPD).In a randomised crossover trial, we compared the acute effect of immediate-release oral morphine
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.