ArticleEMBO molecular medicine2017
iPhemap: an atlas of phenotype to genotype relationships of human iPSC models of neurological diseases.
Article in EMBO molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- BK channel activity in skin fibroblasts from patients with neurological disorder.Channels (Austin, Tex.) · 2025Article
- Application potential of induced pluripotent stem cells in the research and treatment of autoimmune diseases (Review).Molecular medicine reports · 2025Review
- iPSC-derived reactive astrocytes from patients with multiple sclerosis protect cocultured neurons in inflammatory conditions.The Journal of clinical investigation · 2023Article
- 'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies.Trends in pharmacological sciences · 2022Review
- Phenotyping Neurodegeneration in Human iPSCs.Annual review of biomedical data science · 2021Review
- Acquisition of chromosome 1q duplication in parental and genome-edited human-induced pluripotent stem cell-derived neural stem cells results in their higher proliferation rate in vitro and in vivo.Cell proliferation · 2020Article
- Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility.Disease models & mechanisms · 2020Review
- Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation.Stem cell reports · 2019Article
- New age for progressive multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium.Scientific reports · 2018Article
- Somatic mosaicism and neurodevelopmental disease.Nature neuroscience · 2018Review
- Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network.Alzheimer's research & therapy · 2018Article
- iPhemap: an atlas of phenotype to genotype relationships of human iPSC models of neurological diseases.EMBO molecular medicine · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Disease modeling with induced pluripotent stem cells (iPSCs) is creating an abundance of phenotypic information that has become difficult to follow and interpret. Here, we report a systematic analysis of research practices and reporting bias in neurological disease models from 93 published articles. We find heterogeneity in current research practices and a reporting bias toward certain diseases. Moreover, we identified 663 CNS cell-derived phenotypes from 243 patients and 214 controls, which varied by mutation type and developmental stage
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.