Evidence map›Paper›PMID 29051214›Full record

SynthesisJournal of the American Heart Association2017

24-Hour Blood Pressure Variability Assessed by Average Real Variability: A Systematic Review and Meta-Analysis.

Luis J Mena, Vanessa G Felix, Jesus D Melgarejo, Gladys E Maestre

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 9 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 9 syntheses or guidelines pooled it, 211 citations in OpenAlex.

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  19. Short-term water deprivation does not increase blood pressure variability or impair neurovascular function in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Luis J MenaAcademic Unit of Computing, Master Program in Applied Sciences, Universidad Politecnica de Sinaloa, Mazatlan, Mexico lmena@upsin.edu.mx.
Vanessa G FelixAcademic Unit of Computing, Master Program in Applied Sciences, Universidad Politecnica de Sinaloa, Mazatlan, Mexico.
Jesus D MelgarejoNeurosciences Laboratory, Biological Research Institute and Research Institute of Cardiovascular Diseases, Faculty of Medicine, Universidad del Zulia, Maracaibo, Venezuela.
Gladys E MaestreNeurosciences Laboratory, Biological Research Institute and Research Institute of Cardiovascular Diseases, Faculty of Medicine, Universidad del Zulia, Maracaibo, Venezuela.
Universidad Politécnica de SinaloaUniversity of Zulia · VE

Funding

Gene-Environment Interactions in Cognition in Venezuelan FamiliesR01AG036469 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHACON, INARA, MAESTRE, GLADYS E. · 2011 to 2015
$2.7M
A longitudinal study of mid-to late-life blood pressure profiles as risk factors for Alzheimer´s disease in HispanicsR03AG054186 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAESTRE, GLADYS E., TERWILLIGER, JOSEPH DOUGLAS · 2016 to 2017
$163k
NIA NIH HHS R01 AG036469NIA NIH HHS R03 AG054186
6 · The paper itself

Abstract

backgroundAlthough 24-hour blood pressure (BP) variability (BPV) is predictive of cardiovascular outcomes independent of absolute BP levels, it is not regularly assessed in clinical practice. One possible limitation to routine BPV assessment is the lack of standardized methods for accurately estimating 24-hour BPV. We conducted a systematic review to assess the predictive power of reported BPV indexes to address appropriate quantification of 24-hour BPV, including the average real variability (ARV) index. METHODS AND

resultsStudies chosen for review were those that presented data for 24-hour BPV in adults from meta-analysis, longitudinal or cross-sectional design, and examined BPV in terms of the following issues: (1) methods used to calculate and evaluate ARV; (2) assessment of 24-hour BPV determined using noninvasive ambulatory BP monitoring; (3) multivariate analysis adjusted for covariates, including some measure of BP; (4) association of 24-hour BPV with subclinical organ damage; and (5) the predictive value of 24-hour BPV on target organ damage and rate of cardiovascular events. Of the 19 assessed studies, 17 reported significant associations between high ARV and the presence and progression of subclinical organ damage, as well as the incidence of hard end points, such as cardiovascular events. In all these cases, ARV remained a significant independent predictor (

conclusionsCurrent evidence suggests that ARV index adds significant prognostic information to 24-hour ambulatory BP monitoring and is a useful approach for studying the clinical value of BPV.

Indexed as

Blood PressureCircadian RhythmAdultAgedBlood Pressure Monitoring, AmbulatoryCardiovascular DiseasesFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisReproducibility of ResultsRisk AssessmentRisk FactorsTime Factorsblood pressure variabilitycardiovascular eventstarget organ damage

Identifiers

PMID29051214
PMCPMC5721878
OpenAlexW2766547216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.