ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2018
Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Probiotic Bifidobacterium Confers Protection Against Heat Stroke Through Enhancement of Intestinal Barrier Function in Rats.Shock (Augusta, Ga.) · 2026Article
- Plant-protein supplementation improves thermoregulatory responses and ameliorates markers of intestinal damage during exercise in the heat.Experimental physiology · 2026Article
- Exercise-induced intestinal barrier dysfunction: a potential contributor to athlete mental health.BMJ open sport & exercise medicine · 2026Article
- Development of a novel organoid-based two-dimensional system to model the intestinal host-parasite interface in fasciolosis.Frontiers in cellular and infection microbiology · 2026Article
- Pharmacological Modulation of the Unfolded Protein Response as a Therapeutic Approach in Cutaneous T-Cell Lymphoma.Biomolecules · 2025Article
- Mechanisms of aerobic exercise effects on the gut microbiota and its metabolites in anxiety disorders.Frontiers in microbiology · 2025Review
- Intestinal gene expression in heat-stressed broilers selected for high water efficiency.Frontiers in physiology · 2025Article
- The Multiple Roles of Heat Shock Proteins in the Development of Inflammatory Bowel Disease.Current molecular medicine · 2025Review
- Review
- Article
- Dietary Strategies to Modulate the Health Condition and Immune Responses in Gilthead Seabream (Animals : an open access journal from MDPI · 2022Article
- Advances of Heat Shock Family in Ulcerative Colitis.Frontiers in pharmacology · 2022Review
- Myron Gordon Award paper: Microbes, T-cell diversity and pigmentation.Pigment cell & melanoma research · 2021Review
- The Effects of a Glucocorticoid Receptor Agonist (GRA) on the Immune Function, Nutrient Digestibility, and Wean-to-Finish Growth Performance of Early-Weaned Pigs.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The inducible heat shock protein 70 (Hsp70) is both cytoprotective and immunomodulatory, potentially accounting for its critical role in maintaining gastrointestinal homeostasis. When levels are reduced in conditions like inflammatory bowel diseases (IBD), loss of function contributes to the severity and chronicity of these diseases, although through which cell types and mechanisms remains unclear. Here, the role of Hsp70-mediated intestinal epithelial protection and immune regulation in experimental colitis was examined by using a villin promoter-driven Hsp70 transgene in the 2,4,6-trinitrobenzene sulfonic acid (TNBS) and dextran sodium sulfate (DSS) models and in IL-10/Hsp70 double knockout (IL10
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.