Evidence map›Paper›PMID 29051114›Full record

ArticleJournal of pain and symptom management2018

Changes in the Occurrence, Severity, and Distress of Symptoms in Patients With Gastrointestinal Cancers Receiving Chemotherapy.

Ilufredo Y Tantoy, Bruce A Cooper, Anand Dhruva, Janine Cataldo, Steven M Paul, Yvette P Conley, Marilyn Hammer, Fay Wright, Laura B Dunn, Jon D Levine and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain and symptom management, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  9. A cancer survivorship model for holistic cancer care and research.Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2023
    Article
  10. Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2023
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  11. Article
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  13. Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ilufredo Y TantoySchool of Nursing, University of California, San Francisco, California, USA.
Bruce A CooperSchool of Nursing, University of California, San Francisco, California, USA.
Anand DhruvaSchool of Medicine, University of California, San Francisco, California, USA.
Janine CataldoSchool of Nursing, University of California, San Francisco, California, USA.
Steven M PaulSchool of Nursing, University of California, San Francisco, California, USA.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Marilyn HammerDepartment of Nursing, Mount Sinai Medical Center, New York, New York, USA.
Fay WrightSchool of Nursing, Yale University, New Haven, Connecticut, USA.
Laura B DunnSchool of Medicine, Stanford University, Palo Alto, California, USA.
Jon D LevineSchool of Medicine, University of California, San Francisco, California, USA.
Christine MiaskowskiSchool of Nursing, University of California, San Francisco, California, USA. Electronic address: chris.miaskowski@ucsf.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NURSING RESEARCH TRAINING IN SYMPTOM MANAGEMENTT32NR007088 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, KATHRYN · 1996 to 2015
$7.5M
Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
Research Training: Self and Family ManagementT32NR008346 · NINR · YALE UNIVERSITY · PI GREY, MARGARET · 2003 to 2018
$4.7M
Advancing the Science of Symptom Management in Oncology PatientsK05CA168960 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2013 to 2017
$453k
NCATS NIH HHS UL1 TR001863NCI NIH HHS K05 CA168960NCI NIH HHS R01 CA134900NINR NIH HHS T32 NR007088NINR NIH HHS T32 NR008346
6 · The paper itself

Abstract

contextStudies on multiple dimensions of the symptom experience of patients with gastrointestinal cancers are extremely limited.

objectivePurpose was to evaluate for changes over time in the occurrence, severity, and distress of seven common symptoms in these patients.

methodsPatients completed Memorial Symptom Assessment Scale, six times over two cycles of chemotherapy (CTX). Changes over time in occurrence, severity, and distress of pain, lack of energy, nausea, feeling drowsy, difficulty sleeping, and change in the way food tastes were evaluated using multilevel regression analyses. In the conditional models, effects of treatment group (i.e., with or without targeted therapy), age, number of metastatic sites, time from cancer diagnosis, number of prior cancer treatments, cancer diagnosis, and CTX regimen on enrollment levels, as well as the trajectories of symptom occurrence, severity, and distress were evaluated.

resultsAlthough the occurrence rates for pain, lack of energy, feeling drowsy, difficulty sleeping, and change in the way food tastes declined over the two cycles of CTX, nausea and numbness/tingling in hands/feet had more complex patterns of occurrence. Severity and distress ratings for the seven symptoms varied across the two cycles of CTX.

conclusionsDemographic and clinical characteristics associated with differences in enrollment levels as well as changes over time in occurrence, severity, and distress of these seven common symptoms were highly variable. These findings can be used to identify patients who are at higher risk for more severe and distressing symptoms during CTX and to enable the initiation of preemptive symptom management interventions.

Indexed as

Disease ProgressionFatigueFemaleGastrointestinal NeoplasmsHumansHypesthesiaLongitudinal StudiesMaleMiddle AgedNauseaPainSeverity of Illness IndexSleep Wake DisordersStress, Psychologicalchemotherapydistressfatiguefeeling drowsyGastrointestinal cancerpainseveritysleep disturbancetargeted therapytaste changes

Identifiers

PMID29051114
PMCPMC5834370

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.