ArticleThe American journal of psychiatry2018
Late-Onset ADHD Reconsidered With Comprehensive Repeated Assessments Between Ages 10 and 25.
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Article in The American journal of psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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62citing papers in PubMed, 1 pooled it
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.
- Adult-Onset ADHD: A Critical Analysis and Alternative Explanations.Child psychiatry and human development · 2022Pooled it
- Childhood ADHD and Its Adult Mimics: When First-Time ADHD Diagnoses in Adulthood May Reflect Other Conditions-A Narrative Review.Brain sciences · 2026Review
- Self-Reported ADHD Symptoms and Cognitive Performance in a National Sample of US Older Adults.Journal of attention disorders · 2026Article
- Article
- Towards Ecological Validity When Assessing ADHD Symptoms: Patterns in Automatically Collected, Real-World PC Activity Data.International journal of human-computer studies · 2026Article
- Adult-diagnosed and childhood-diagnosed attention deficit/hyperactivity disorder: cognitive and environmental contributions to symptom severity across different age of diagnosis.Frontiers in psychiatry · 2026Article
- Attention-deficit/hyperactivity disorder (ADHD) in adults: evidence base, uncertainties and controversies.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Commentary on Sources of Attention-Deficit/Hyperactivity Overdiagnosis Among U.S. Adults.Healthcare (Basel, Switzerland) · 2025Article
- Joint Factor Performance Validity?-Network and Factor Structure of Performance Validity Measures in the Clinical Evaluation of Adult ADHD.Behavioral sciences (Basel, Switzerland) · 2025Article
- Pathways to autism diagnosis in adulthood.Journal of neurodevelopmental disorders · 2025Article
- Differentiating Between Methylphenidate Use and Misuse: Clinical Insights From University Students and Academic Staff in Türkiye.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- ADHD and Alcohol Use Disorder: Optimizing Screening and Treatment in Co-occurring Conditions.CNS drugs · 2025Review
- Large-scale analysis reveals racial disparities in the prevalence of ADHD and conduct disorders.Scientific reports · 2024Article
- Neurocognitive Characteristics of Patients Who Visited a Psychiatric Outpatient Clinic Requesting Treatment for Adult Attention-Deficit/Hyperactivity Disorder.Psychiatry investigation · 2024Article
- Attention-deficit/hyperactivity disorder.Nature reviews. Disease primers · 2024Review
- ADDing up?Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists · 2024Article
- Assessing aetiological overlap between child and adult attention-deficit hyperactivity disorder symptoms in an extended family design.BJPsych open · 2023Article
- First-time diagnosis of ADHD in adults: challenge to retrospectively assess childhood symptoms of ADHD from long-term memory.European child & adolescent psychiatry · 2023Article
- Annual Research Review: Perspectives on progress in ADHD science - from characterization to cause.Journal of child psychology and psychiatry, and allied disciplines · 2023Review
- Sex and gender in neurodevelopmental conditions.Nature reviews. Neurology · 2023Review
2 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 1 institution in 2 countries.
Margaret H SibleyFrom the Department of Psychiatry and Behavioral Health, Florida International University, Miami; the Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; the Child Development Center, School of Medicine, University of California, Irvine; the Division of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada; the Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.; the Department of Psychiatry, Ohio State University, Nisonger Center, Columbus, Ohio; the Division of Molecular Psychiatry, University Hospital Wuerzberg, Germany; and the Department of Pediatrics, University of California, Irvine.
Luis A RohdeFrom the Department of Psychiatry and Behavioral Health, Florida International University, Miami; the Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; the Child Development Center, School of Medicine, University of California, Irvine; the Division of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada; the Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.; the Department of Psychiatry, Ohio State University, Nisonger Center, Columbus, Ohio; the Division of Molecular Psychiatry, University Hospital Wuerzberg, Germany; and the Department of Pediatrics, University of California, Irvine.
James M SwansonFrom the Department of Psychiatry and Behavioral Health, Florida International University, Miami; the Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; the Child Development Center, School of Medicine, University of California, Irvine; the Division of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada; the Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.; the Department of Psychiatry, Ohio State University, Nisonger Center, Columbus, Ohio; the Division of Molecular Psychiatry, University Hospital Wuerzberg, Germany; and the Department of Pediatrics, University of California, Irvine.
Lily T HechtmanFrom the Department of Psychiatry and Behavioral Health, Florida International University, Miami; the Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; the Child Development Center, School of Medicine, University of California, Irvine; the Division of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada; the Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.; the Department of Psychiatry, Ohio State University, Nisonger Center, Columbus, Ohio; the Division of Molecular Psychiatry, University Hospital Wuerzberg, Germany; and the Department of Pediatrics, University of California, Irvine.
Brooke S G MolinaFrom the Department of Psychiatry and Behavioral Health, Florida International University, Miami; the Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; the Child Development Center, School of Medicine, University of California, Irvine; the Division of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada; the Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.; the Department of Psychiatry, Ohio State University, Nisonger Center, Columbus, Ohio; the Division of Molecular Psychiatry, University Hospital Wuerzberg, Germany; and the Department of Pediatrics, University of California, Irvine.
John T MitchellFrom the Department of Psychiatry and Behavioral Health, Florida International University, Miami; the Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; the Child Development Center, School of Medicine, University of California, Irvine; the Division of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada; the Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.; the Department of Psychiatry, Ohio State University, Nisonger Center, Columbus, Ohio; the Division of Molecular Psychiatry, University Hospital Wuerzberg, Germany; and the Department of Pediatrics, University of California, Irvine.
L Eugene ArnoldFrom the Department of Psychiatry and Behavioral Health, Florida International University, Miami; the Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; the Child Development Center, School of Medicine, University of California, Irvine; the Division of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada; the Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.; the Department of Psychiatry, Ohio State University, Nisonger Center, Columbus, Ohio; the Division of Molecular Psychiatry, University Hospital Wuerzberg, Germany; and the Department of Pediatrics, University of California, Irvine.
Arthur CayeFrom the Department of Psychiatry and Behavioral Health, Florida International University, Miami; the Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; the Child Development Center, School of Medicine, University of California, Irvine; the Division of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada; the Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.; the Department of Psychiatry, Ohio State University, Nisonger Center, Columbus, Ohio; the Division of Molecular Psychiatry, University Hospital Wuerzberg, Germany; and the Department of Pediatrics, University of California, Irvine.
Traci M KennedyFrom the Department of Psychiatry and Behavioral Health, Florida International University, Miami; the Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; the Child Development Center, School of Medicine, University of California, Irvine; the Division of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada; the Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.; the Department of Psychiatry, Ohio State University, Nisonger Center, Columbus, Ohio; the Division of Molecular Psychiatry, University Hospital Wuerzberg, Germany; and the Department of Pediatrics, University of California, Irvine.
Arunima RoyFrom the Department of Psychiatry and Behavioral Health, Florida International University, Miami; the Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; the Child Development Center, School of Medicine, University of California, Irvine; the Division of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada; the Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.; the Department of Psychiatry, Ohio State University, Nisonger Center, Columbus, Ohio; the Division of Molecular Psychiatry, University Hospital Wuerzberg, Germany; and the Department of Pediatrics, University of California, Irvine.
Annamarie StehliFrom the Department of Psychiatry and Behavioral Health, Florida International University, Miami; the Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; the Child Development Center, School of Medicine, University of California, Irvine; the Division of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada; the Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.; the Department of Psychiatry, Ohio State University, Nisonger Center, Columbus, Ohio; the Division of Molecular Psychiatry, University Hospital Wuerzberg, Germany; and the Department of Pediatrics, University of California, Irvine.
Multimodal Treatment Study of Children with ADHD (MTA) Cooperative GroupFrom the Department of Psychiatry and Behavioral Health, Florida International University, Miami; the Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; the Child Development Center, School of Medicine, University of California, Irvine; the Division of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada; the Departments of Psychiatry, Psychology, and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.; the Department of Psychiatry, Ohio State University, Nisonger Center, Columbus, Ohio; the Division of Molecular Psychiatry, University Hospital Wuerzberg, Germany; and the Department of Pediatrics, University of California, Irvine.
Universidade Federal do Rio Grande do Sul · BR
Funding
Pathways to adult substance use and abuse from childhood ADHD in the MTAR01DA039881 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 2015 to 2018
$1.1MEmotion Dysregulation, ADHD, and SmokingK23DA032577 · NIDA · DUKE UNIVERSITY · PI MITCHELL, JOHN T · 2012 to 2015
$566kPHARMACOLOGIC AND PSYCHOSOCIAL INTERVENTIONS FOR ADHDU01MH050461 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HINSHAW, STEPHEN P · 1992 to 2000
$17kMULTISITE MULTIMODAL TREATMENT STUDY OF ADHD/ADDU01MH050453 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ABIKOFF, HOWARD B · 1992 to 2000
$17kMULTISITE MULTIMODALITY TREATMENT STUDY OF ADHD/ADDU01MH050440 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI SWANSON, JAMES M · 1992 to 2000
$17kPHARMACOLOGICAL AND PSYCHOSOCIAL TREATMENT FOR ADHDU01MH050467 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PELHAM, WILLIAM E · 1992 to 2000
$17kFOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012011N01MH012011 · NIMH · UNIVERSITY OF CALIFORNIA, IRVI · PI SWANSON, JAMES · 2002 to 2006
–FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012012N01MH012012 · NIMH · DUKE UNIVERSITY MEDICAL CENTER · 2002 to 2004
–FOLLOW UP OF THE MULTIMODAL TREATMETN STUDY OF CHILDREN WITH ATTENTION-278012010N01MH012010 · NIMH · UNIVERSITY OF PITTSBURGH · PI SG MOLINA, BROOKE · 2002 to 2006
–FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012009N01MH012009 · NIMH · UNIVERSITY OF CALIFORNIA, BERK · PI HINSHAW, STEPHEN · 2002 to 2006
–FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012008N01MH012008 · NIMH · MCGILL UNIVERSITY · PI HECHTMAN, LILY T. · 2002 to 2006
–FOLLOW UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012007N01MH012007 · NIMH · RES. FOUND. FOR MENTAL HEALTH, · PI GREENHILL, LARRY LEE · 2002 to 2006
–NIDA NIH HHS HHSN271200800003CNIDA NIH HHS HHSN271200800004CNIDA NIH HHS HHSN271200800005CNIDA NIH HHS HHSN271200800006CNIDA NIH HHS HHSN271200800007CNIDA NIH HHS HHSN271200800008CNIDA NIH HHS HHSN271200800009CNIDA NIH HHS K23 DA032577NIDA NIH HHS N01 DA085548NIDA NIH HHS N01 DA085549NIDA NIH HHS N01 DA085550NIDA NIH HHS N01 DA085552NIDA NIH HHS N01 DA085553NIDA NIH HHS N01 DA085554NIDA NIH HHS R01 DA039881NIMH NIH HHS N01 MH012004NIMH NIH HHS N01 MH012007NIMH NIH HHS N01 MH012008NIMH NIH HHS N01 MH012009NIMH NIH HHS N01 MH012010NIMH NIH HHS N01 MH012011NIMH NIH HHS N01 MH012012NIMH NIH HHS U01 MH050440NIMH NIH HHS U01 MH050453NIMH NIH HHS U01 MH050461NIMH NIH HHS U01 MH050467
Abstract
objectiveAdolescents and young adults without childhood attention deficit hyperactivity disorder (ADHD) often present to clinics seeking stimulant medication for late-onset ADHD symptoms. Recent birth-cohort studies support the notion of late-onset ADHD, but these investigations are limited by relying on screening instruments to assess ADHD, not considering alternative causes of symptoms, or failing to obtain complete psychiatric histories. The authors address these limitations by examining psychiatric assessments administered longitudinally to the local normative comparison group of the Multimodal Treatment Study of ADHD.
methodIndividuals without childhood ADHD (N=239) were administered eight assessments from comparison baseline (mean age=9.89 years) to young adulthood (mean age=24.40 years). Diagnostic procedures utilized parent, teacher, and self-reports of ADHD symptoms, impairment, substance use, and other mental disorders, with consideration of symptom context and timing.
resultsApproximately 95% of individuals who initially screened positive on symptom checklists were excluded from late-onset ADHD diagnosis. Among individuals with impairing late-onset ADHD symptoms, the most common reason for diagnostic exclusion was symptoms or impairment occurring exclusively in the context of heavy substance use. Most late-onset cases displayed onset in adolescence and an adolescence-limited presentation. There was no evidence for adult-onset ADHD independent of a complex psychiatric history.
conclusionsIndividuals seeking treatment for late-onset ADHD may be valid cases; however, more commonly, symptoms represent nonimpairing cognitive fluctuations, a comorbid disorder, or the cognitive effects of substance use. False positive late-onset ADHD cases are common without careful assessment. Clinicians should carefully assess impairment, psychiatric history, and substance use before treating potential late-onset cases.
Indexed as
CognitionAdolescentAdultAge of OnsetAttention Deficit Disorder with HyperactivityCase-Control StudiesChildComorbidityFemaleHumansMaleSubstance-Related DisordersYoung AdultAttention Deficit Hyperactivity DisorderDiagnosis And Classification
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