Evidence map›Paper›PMID 29050390›Full record

ArticleBrain : a journal of neurology2017

Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy.

Adam R Neumann, Robrecht Raedt, Hendrik W Steenland, Mathieu Sprengers, Katarzyna Bzymek, Zaneta Navratilova, Lilia Mesina, Jeanne Xie, Valerie Lapointe, Fabian Kloosterman and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain : a journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 55 citations in OpenAlex.

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  16. GABACurrent neuropharmacology · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Adam R NeumannDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Robrecht RaedtDepartment of Neurology, Ghent University, Gent, Belgium.
Hendrik W SteenlandDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Mathieu SprengersDepartment of Neurology, Ghent University, Gent, Belgium.
Katarzyna BzymekDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Zaneta NavratilovaDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Lilia MesinaDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Jeanne XieDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Valerie LapointeDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Fabian KloostermanNeuro-Electronics Research Flanders, Leuven, Belgium.
Kristl VonckDepartment of Neurology, Ghent University, Gent, Belgium.
Paul A J M BoonDepartment of Neurology, Ghent University, Gent, Belgium.
Ivan SolteszDepartment of Neurosurgery, and Stanford Neurosciences Institute, Stanford University, Stanford, CA, USA.
Bruce L McNaughtonDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Artur LuczakDepartment of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
University of Lethbridge · CAGhent University · BENeuroelectronics Research Flanders · BENeurosciences Institute · USVIB-KU Leuven Center for Brain & Disease Research · BE

Funding

Plasticity of GABAergic Inhibition Following Head InjuryR01NS035915 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SOLTESZ, IVAN · 2002 to 2017
$2.6M
Plasticity Of GABAergic Inhibition Following Head InjuryR37NS035915 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SOLTESZ, IVAN · 2005 to 2011
$2.5M
PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURYR29NS035915 · NINDS · UNIVERSITY OF CALIFORNIA IRVINE · PI SOLTESZ, IVAN · 1997 to 2001
$273k
NINDS NIH HHS R01 NS035915NINDS NIH HHS R29 NS035915NINDS NIH HHS R37 NS035915
6 · The paper itself

Abstract

See Lenck-Santini (doi:10.1093/awx205) for a scientific commentary on this article. Epileptic seizures represent altered neuronal network dynamics, but the temporal evolution and cellular substrates of the neuronal activity patterns associated with spontaneous seizures are not fully understood. We used simultaneous recordings from multiple neurons in the hippocampus and neocortex of rats with chronic temporal lobe epilepsy to demonstrate that subsets of cells discharge in a highly stereotypical sequential pattern during ictal events, and that these stereotypical patterns were reproducible across consecutive seizures. In contrast to the canonical view that principal cell discharges dominate ictal events, the ictal sequences were predominantly composed of fast-spiking, putative inhibitory neurons, which displayed unusually strong coupling to local field potential even before seizures. The temporal evolution of activity was characterized by unique dynamics where the most correlated neuronal pairs before seizure onset displayed the largest increases in correlation strength during the seizures. These results demonstrate the selective involvement of fast spiking interneurons in structured temporal sequences during spontaneous ictal events in hippocampal and neocortical circuits in experimental models of chronic temporal lobe epilepsy.

Indexed as

AnimalsChronic DiseaseEpilepsy, Temporal LobeHippocampusInterneuronsMaleNeocortexRatsSeizuresTemporal Lobeneuronal population activity, GABAergic cellstemporal lobe epilepsy

Identifiers

PMID29050390
PMCPMC6248724
OpenAlexW2743764291

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.