ArticleOncotarget2017
Negative lymph node count is a significant prognostic factor in patient with stage IV gastric cancer after palliative gastrectomy.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Historical evolution and current research status of lymph node staging in gastric cancer: a review.World journal of surgical oncology · 2025Review
- Clinical Association of Negative Lymph Nodes With Adjuvant Chemotherapy in Patients With T3N0 Rectal Cancer.Gastroenterology research and practice · 2025Article
- Article
- Impact of the extent of negative lymph nodes in gastric adenocarcinoma undergoing primary surgical resection: An institutional report.Journal of the Chinese Medical Association : JCMA · 2021Article
- Involvement of SLC39A6 in gastric adenocarcinoma and correlation of the SLC39A6 polymorphism rs1050631 with clinical outcomes after resection.BMC cancer · 2019Article
- Impact of negative lymph nodes on colon cancer survival and exploring relevant transcriptomics differences through real-world data analyses.Annals of translational medicine · 2019Article
- Nomograms for predicting survival in patients with metastatic gastric adenocarcinoma who undergo palliative gastrectomy.BMC cancer · 2019Article
- Metastatic lymph node ratio as a prognostic indicator in patients with stage IV colon cancer undergoing resection.Journal of Cancer · 2019Article
- MicroRNA-214 promotes the proliferation, migration and invasion of gastric cancer MKN28 cells by suppressing the expression of Dact2.Experimental and therapeutic medicine · 2018Article
- An increased number of negative lymph nodes is associated with a higher immune response and longer survival in colon cancer patients.Cancer management and research · 2018Article
- The appropriate number of ELNs for lymph node negative breast cancer patients underwent MRM: a population-based study.Oncotarget · 2017Article
- Establishment and Validation of a Nomogram Based on Negative Lymph Nodes to Predict Survival in Postoperative Patients with non-Small Cell Lung Cancer.Technology in cancer research & treatmentArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Negative lymph node (NLN) count has been validated as a protective predictor in various cancers after radical resection. However, the prognostic value of NLN count in the setting of stage IV gastric cancer patients who have received palliative resection has not been investigated. Surveillance, Epidemiology, and End Results Program (SEER)-registered gastric cancer patients were used for analysis in this study. Kaplan-Meier survival curves and multivariate Cox proportional hazards model were used to assess the risk factors for patients' survivals. The results showed that NLN count and N stage were independently prognostic factors in patients with stage IV gastric cancer after palliative surgery (P< 0.001). X-tile plots identified 2 and 11 as the optimal cutoff values to divide the patients into high, middle and low risk subsets in term of cause-specific survival (CSS). And NLN count was proved to be an independently prognostic factor in multivariate Cox analysis (P< 0.001). The risk score of NLN counts demonstrated that the plot of hazard ratios (HRs) for NLN counts sharply increased when the number of NLN counts decreased. Collectively, our present study revealed that NLN count was an independent prognostic predictor in stage IV gastric cancer after palliative resection. Standard lymph node dissection, such as D2 lymphadectomy maybe still necessary during palliative resection for patients with metastatic gastric cancer.
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