ArticleOncotarget2017
Tumor-infiltrating B cells producing antitumor active immunoglobulins in resected HCC prolong patient survival.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Activating a B cell immune response regresses immunologically cold tumours.Nature nanotechnology · 2026Article
- Article
- Multifaceted function of B cells in tumorigenesis.Frontiers of medicine · 2025Review
- Review
- Immune characteristics of dedifferentiated retroperitoneal liposarcomas and the reliability of regional samples in evaluating their tumor immune microenvironments.World journal of surgical oncology · 2024Article
- Elevated NDC1 expression predicts poor prognosis and correlates with immunity in hepatocellular carcinoma.Journal of gastrointestinal oncology · 2023Article
- The Functional Roles of Immune Cells in Primary Liver Cancer.The American journal of pathology · 2022Review
- M2-like tumor-associated macrophage-related biomarkers to construct a novel prognostic signature, reveal the immune landscape, and screen drugs in hepatocellular carcinoma.Frontiers in immunology · 2022Article
- Approaches to spatially resolving the tumour immune microenvironment of hepatocellular carcinoma.Therapeutic advances in medical oncology · 2022Review
- Preoperative Prognostic Nutritional Index May Be a Strong Predictor of Hepatocellular Carcinoma Recurrence Following Liver Transplantation.Journal of hepatocellular carcinoma · 2022Article
- Prognostic value of tumor-infiltrating B lymphocytes and plasma cells in triple-negative breast cancer.Breast cancer (Tokyo, Japan) · 2021Article
- Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC.International journal of molecular sciences · 2021Review
- Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies.Oncoimmunology · 2021Review
- Current Perspectives on B Lymphocytes in the Immunobiology of Hepatocellular Carcinoma.Frontiers in oncology · 2021Review
- A role for the immune system in advanced laryngeal cancer.Scientific reports · 2020Article
- Immunological distinctions between nonalcoholic steatohepatitis and hepatocellular carcinoma.Experimental & molecular medicine · 2020Review
- Prediction of overall survival in resectable intrahepatic cholangiocarcinoma: ISCancer science · 2020Article
- Promising key genes associated with tumor microenvironments and prognosis of hepatocellular carcinoma.World journal of gastroenterology · 2020Article
- Emerging Role of the Pathologist in Precision Medicine for HCC.Digestive diseases and sciences · 2019Review
- Deceleration of glycometabolism impedes IgG-producing B-cell-mediated tumor elimination by targeting SATB1.Immunology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsThe immunological microenvironment of HCC influences patient outcome, however, the role of B cells remains unclear. This study investigated effects of local B-cell infiltration in HCC cohorts on patient survival and immunological and molecular tumor microenvironment.
resultsUnsupervised gene expression analysis of full cancer transcriptomes (N=2158) revealed a highly co-regulated immunological cluster in HCC that mainly contained immunoglobulin fragments. More specifically, in an independent patient cohort (N=242) that compares HCC with non tumorous liver tissue high expression of these B-cell associated genes was associated with better patient outcome (P=0.0149). Conclusively, the immunohistochemical analysis of another independent cohort of resected HCCs (N=119) demonstrated that infiltration of HCCs by CD20
methodsGene expression of 2 independent HCC tissue databases was compared using microarrays. Additionally, tissue of resected HCCs was stained for CD20, CD79a and immunoglobulins and analysed for the respective cell numbers separately for tumor, infiltrative margin and distant liver stroma. These findings were correlated with clinical data and patient outcome.
conclusionsInfiltration of HCCs by B cells is associated with prolonged patient survival. Further, a distinct B-cell like immunoglobulin profile of HCCs was identified that goes along with better patient outcome. We suggest that B cells contribute to local tumor control by secreting increased levels of immunoglobulins with antitumor activity.
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