Evidence map›Paper›PMID 29050306›Full record

ArticleOncotarget2017

The hyaluronan-mediated motility receptor RHAMM promotes growth, invasiveness and dissemination of colorectal cancer.

Valentina Mele, Lena Sokol, Viktor Hendrik Kölzer, Dennis Pfaff, Manuele Giuseppe Muraro, Irene Keller, Zahnd Stefan, Irene Centeno, Luigi Maria Terracciano, Heather Dawson and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 63 citations in OpenAlex.

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  12. Friend or foe? The elusive role of hepatic stellate cells in liver cancer.Nature reviews. Gastroenterology & hepatology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Valentina MeleCancer Immunotherapy, Department of Biomedicine, University of Basel, Basel, Switzerland.
Lena SokolTranslational Research Unit, Institute of Pathology, University of Bern, Bern, Switzerland.
Viktor Hendrik KölzerCantonal Hospital Baselland, Institute of Pathology, Liestal, Switzerland.
Dennis PfaffCell Signaling, Department of Biomedicine, University of Basel, Basel, Switzerland.
Manuele Giuseppe MuraroOncology Surgery and Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Irene KellerDepartment of Clinical Research and Swiss Institute of Bioinformatics, University of Bern, Bern, Switzerland.
Zahnd StefanTranslational Research Unit, Institute of Pathology, University of Bern, Bern, Switzerland.
Irene CentenoTranslational Research Unit, Institute of Pathology, University of Bern, Bern, Switzerland.
Luigi Maria TerraccianoMolecular Pathology Division, Institute of Pathology, University Hospital, Basel, Switzerland.
Heather DawsonClinical Pathology Division, Institute of Pathology, University of Bern, Bern, Switzerland.
Inti ZlobecTranslational Research Unit, Institute of Pathology, University of Bern, Bern, Switzerland.
Giandomenica IezziCancer Immunotherapy, Department of Biomedicine, University of Basel, Basel, Switzerland.
Alessandro LugliClinical Pathology, Institute of Pathology, University Hospital, Basel, Switzerland.
University of Bern · CHUniversity of Basel · CHUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In colorectal cancer (CRC), RHAMM is an independent adverse prognostic factor. The aim of the study was therefore to investigate on the role of RHAMM as a potential direct driver of cell proliferation and migration in CRC cell lines and to identify pathways dependent on RHAMM in human CRC. Proliferation, cell cycle alterations and invasive capacity were tested in two RHAMM- and control- knockdown CRC cell lines by flow cytometry and

Indexed as

colorectal cancerinvasionmetastasisproliferationRHAMM

Identifiers

PMID29050306
PMCPMC5642581
OpenAlexW2742269031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.