Evidence map›Paper›PMID 29050297›Full record

ArticleOncotarget2017

Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells.

Marina O Gomzikova, Margarita N Zhuravleva, Regina R Miftakhova, Svetlana S Arkhipova, Vladimir G Evtugin, Svetlana F Khaiboullina, Andrey P Kiyasov, Jenny L Persson, Nigel P Mongan, Richard G Pestell and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Methods of the Large-Scale Production of Extracellular Vesicles.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Membrane Microvesicles as Potential Vaccine Candidates.International journal of molecular sciences · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 5 countries.

Marina O GomzikovaKazan Federal University, Kazan, 420008, Russia.
Margarita N ZhuravlevaKazan Federal University, Kazan, 420008, Russia.
Regina R MiftakhovaKazan Federal University, Kazan, 420008, Russia.
Svetlana S ArkhipovaKazan Federal University, Kazan, 420008, Russia.
Vladimir G EvtuginKazan Federal University, Kazan, 420008, Russia.
Svetlana F KhaiboullinaKazan Federal University, Kazan, 420008, Russia.
Andrey P KiyasovKazan Federal University, Kazan, 420008, Russia.
Jenny L PerssonDepartment of Translational Medicine, Lund University, 205 02 Malmö, and Department of Molecular Biology, 901 87 Umeå, Umeå University.
Nigel P MonganCancer Biology and Translational Research, School of Veterinary Medicine and Science, University of Nottingham, LE12 5RD, UK.
Richard G PestellPennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Pennsylvania Biotechnology Center, 100 East Lancaster Avenue, Suite, 222, Wynnewood, PA 19096. USA.
Albert A RizvanovKazan Federal University, Kazan, 420008, Russia.
Kazan Federal University · RUNanyang Technological University · SGUmeå University · SEWeill Cornell Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Naturally occurring extracellular vesicles (EVs) play essential roles in intracellular communication and delivery of bioactive molecules. Therefore it has been suggested that EVs could be used for delivery of therapeutics. However, to date the therapeutic application of EVs has been limited by number of factors, including limited yield and full understanding of their biological activities. To address these issues, we analyzed the morphology, molecular composition, fusion capacity and biological activity of Cytochalasin B-induced membrane vesicles (CIMVs). The size of these vesicles was comparable to that of naturally occurring EVs. In addition, we have shown that CIMVs from human SH-SY5Y cells contain elevated levels of VEGF as compared to the parental cells, and stimulate angiogenesis

Indexed as

angiogenesiscell-free therapycytochalasin B-induced membrane vesiclesextracellular vesiclesmembrane vesicles

Identifiers

PMID29050297
PMCPMC5642572
OpenAlexW2740208777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.