ArticleOncotarget2017
Reverse phase protein array identification of triple-negative breast cancer subtypes and comparison with mRNA molecular subtypes.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Multi-Omics Integration Identifies Ferroptosis-Related miRNA-mRNA Networks and Independent Prognostic miRNAs in Triple-Negative Breast Cancer.Journal of clinical practice and research · 2026Article
- Role of immunosuppressive JNK pathway in the tumor microenvironment among TNBC subtypes in IBCSG trial 22-00.iScience · 2025Article
- Molecular Mechanisms Underlying Amyloid Beta Peptide Mediated Upregulation of Vascular Cell Adhesion Molecule-1 in Alzheimer Disease.The Journal of pharmacology and experimental therapeutics · 2024Article
- Mesenchymal-like immune-altered is the fourth robust triple-negative breast cancer molecular subtype.Breast cancer (Tokyo, Japan) · 2024Article
- Review
- Radiomics in Triple Negative Breast Cancer: New Horizons in an Aggressive Subtype of the Disease.Journal of clinical medicine · 2022Review
- Identification of the JNK-Active Triple-Negative Breast Cancer Cluster Associated With an Immunosuppressive Tumor Microenvironment.Journal of the National Cancer Institute · 2022Article
- Article
- Current Triple-Negative Breast Cancer Subtypes: Dissecting the Most Aggressive Form of Breast Cancer.Frontiers in oncology · 2021Review
- Protein expression profiling identifies differential modulation of homologous recombination by platinum-based antitumor agents.Cancer chemotherapy and pharmacology · 2020Article
- Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill.Molecular pharmacology · 2020Article
- Network-Based Matching of Patients and Targeted Therapies for Precision Oncology.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2020Article
- Protein biomarkers for subtyping breast cancer and implications for future research.Expert review of proteomics · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundReverse phase protein array (RPPA) analysis, allows investigation of potential targets at the functional protein level,. We identified TNBC subtypes at the protein level using RPPA and compared them with mRNA molecular subtypes (TNBCtype, TNBCtype-4, and PAM50) that is unique in its availability of both RPPA and mRNA analyses.
methodsWe classified the samples from 80 TNBC patients using both k-means and hierarchical consensus clustering analysis and performed Ingenuity Pathway Analysis. We also investigated whether we could reproduce the mRNA molecular subtypes using the RPPA dataset.
resultsBoth clustering methods divided all samples into 2 clusters that were biologically the same. The top canonical pathways included inflammation, hormonal receptors, and MAPK signaling pathways for the first cluster ["inflammation and hormonal-related (I/H) subtype"] and the GADD45, DNA damage, and p53 signaling pathways for the second cluster ["DNA damage (DD)-related subtype"]. Further k-means cluster analysis identified 5 TNBC clusters. Comparison between sample classification using the 5 RPPA-based k-means cluster subtypes and 6 gene-expression-based TNBCtype molecular subtypes showed significant association between the 2 classifications (p = 0.017).
conclusionsThe I/H and DD subtypes identified by RPPA advance our understanding of TNBC's heterogeneity from the functional proteomic perspective.
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