Evidence map›Paper›PMID 29049877›Full record

ArticleThe Journal of organic chemistry2017

Synthesis of 5'-Thio-3'-O-ribonucleoside Phosphoramidites.

Nan-Sheng Li, Jun Lu, Joseph A Piccirilli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Synthesis of Oligoribonucleotides Containing a 2'-Amino-5'-The Journal of organic chemistry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nan-Sheng LiDepartment of Biochemistry & Molecular Biology and Department of Chemistry, University of Chicago , 929 East 57th Street, Chicago, Illinois 60637, United States.ORCID 0000-0002-1185-3688
Jun LuDepartment of Biochemistry & Molecular Biology and Department of Chemistry, University of Chicago , 929 East 57th Street, Chicago, Illinois 60637, United States.
Joseph A PiccirilliDepartment of Biochemistry & Molecular Biology and Department of Chemistry, University of Chicago , 929 East 57th Street, Chicago, Illinois 60637, United States.ORCID 0000-0002-0541-6270
University of Chicago · US

Funding

The Catalytic Mechanism of Nuclear Premessenger RNA Splicing by the SpliceosomeR01GM088656 · NIGMS · UNIVERSITY OF CHICAGO · PI PICCIRILLI, JOSEPH ANTHONY, STALEY, JONATHAN P · 2010 to 2017
$4.2M
Investigating the Catalytic Mechanism of the HDV RibozymeR01AI081987 · NIAID · UNIVERSITY OF CHICAGO · PI PICCIRILLI, JOSEPH ANTHONY · 2010 to 2014
$1.8M
NIAID NIH HHS R01 AI081987NIGMS NIH HHS R01 GM088656
6 · The paper itself

Abstract

The chemical synthesis of phosphoramidite derivatives of all four 5'-deoxy-5'-thioribonucleosides is described. These phosphoramidites contained trityl (A, G, C, and U), dimethoxytrityl (A and G), or tert-butyldisulfanyl (G) as the 5'-S-protecting group. The application of several of these phosphoramidites for solid-phase synthesis of oligoribonucleotides containing a 2'-O-photocaged 5'-S-phosphorothiolate linkage or 5'-thiol-labeled RNAs is also further investigated.

Indexed as

Molecular StructureOligoribonucleotidesOrganophosphorus CompoundsRibonucleosidesSulfhydryl CompoundsOligoribonucleotidesOrganophosphorus CompoundsphosphoramiditeRibonucleosidesSulfhydryl Compounds

Identifiers

PMID29049877
PMCPMC6557410
OpenAlexW2765598421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.