ArticlePloS one2017
A structural equation model of the relationship between insomnia, negative affect, and paranoid thinking.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials.Sleep medicine reviews · 2021Pooled it
- Sleep and schizophrenia: From epiphenomenon to treatable causal target.Schizophrenia research · 2020Pooled it
- Insomnia contributes to paranoid thoughts through mechanisms involving anxiety and non-constructive rumination.Scientific reports · 2026Article
- Network analysis of neuropsychiatric symptoms in mild behavioral impairment among nursing homes: an observational study.BMC geriatrics · 2025Observational
- The effect of sleep disturbance trajectories on psychotic-like experiences among adolescents: the mediating role of depressive symptoms.European child & adolescent psychiatry · 2025Article
- Sleep and circadian difficulties in schizophrenia: presentations, understanding, and treatment.Psychological medicine · 2025Review
- The revised GreenPsychological medicine · 2021Article
- Positive and Negative Affect Mediate the Influences of a Maladaptive Emotion Regulation Strategy on Sleep Quality.Frontiers in psychiatry · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA growing body of evidence points to relationships between insomnia, negative affect, and paranoid thinking. However, studies are needed to examine (i) whether negative affect mediates the relation between insomnia and paranoid thinking, (ii) whether different types of insomnia exert different effects on paranoia, and (iii) to compare the impact of objective and self-reported sleeping difficulties.
methodStructural equation modelling was therefore used to test competing models of the relationships between self-reported insomnia, negative affect, and paranoia. n = 348 participants completed measures of insomnia, negative affect and paranoia. A subset of these participants (n = 91) went on to monitor their sleep objectively (using a portable sleep monitor made by Zeo) for seven consecutive nights. Associations between objectively recorded sleep, negative affect, and paranoia were explored using linear regression.
resultsThe findings supported a fully mediated model where self-reported delayed sleep onset, but not self-reported problems with sleep maintenance or objective measures of sleep, was directly associated with negative affect that, in turn, was associated with paranoia. There was no evidence of a direct association between delayed sleep onset or sleep maintenance problems and paranoia.
conclusionsTaken together, the findings point to an association between perceived (but not objective) difficulties initially falling asleep (but not maintaining sleep) and paranoid thinking; a relationship that is fully mediated by negative affect. Future research should seek to disentangle the causal relationships between sleep, negative affect, and paranoia (e.g., by examining the effect of an intervention using prospective designs that incorporate experience sampling). Indeed, interventions might profitably target (i) perceived sleep quality, (ii) sleep onset, and / or (iii) emotion regulation as a route to reducing negative affect and, thus, paranoid thinking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.