ArticlePLoS pathogens2017
Parallel and costly changes to cellular immunity underlie the evolution of parasitoid resistance in three Drosophila species.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Geographic Variation in Resistance of the InvasiveEvolutionary applications · 2025Article
- Strength of Enemy Release From Parasitoids Is Context Dependent in the Invasive African Fig Fly,Ecology and evolution · 2025Article
- Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids.Current biology : CB · 2025Article
- Multigenerational inheritance of parasitic stress memory inEnvironmental epigenetics · 2025Article
- Article
- Strength of enemy release from parasitoids is context-dependent in the invasive African Fig Fly,bioRxiv : the preprint server for biology · 2024Article
- Article
- AVirulence · 2023Article
- Natural selection has driven the recurrent loss of an immunity gene that protectsProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Activation of immune defences against parasitoid wasps does not underlie the cost of infection.Frontiers in immunology · 2023Article
- The Cellular Immunological Responses and Developmental Differences between Two Hosts Parasitized byLife (Basel, Switzerland) · 2022Article
- Differential activation of JAK-STAT signaling reveals functional compartmentalization ineLife · 2021Article
- Constitutive activation of cellular immunity underlies the evolution of resistance to infection ineLife · 2020Article
- Genetic variation for resistance to the specific fly pathogen Entomophthora muscae.Scientific reports · 2020Article
- Sexual selection reveals a cost of pathogen resistance undetected in life-history assays.Evolution; international journal of organic evolution · 2020Article
- Maternal Priming of Offspring Immune System inG3 (Bethesda, Md.) · 2020Article
- Variation in intrinsic resistance of pea aphids to parasitoid wasps: A transcriptomic basis.PloS one · 2020Article
- Host density and parasitoid presence interact and shape the outcome of a tritrophic interaction on seeds of wild lima bean.Scientific reports · 2019Article
- Independent effects on cellular and humoral immune responses underlie genotype-by-genotype interactions between Drosophila and parasitoids.PLoS pathogens · 2019Article
- Article
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6 authors.
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Abstract
A priority for biomedical research is to understand the causes of variation in susceptibility to infection. To investigate genetic variation in a model system, we used flies collected from single populations of three different species of Drosophila and artificially selected them for resistance to the parasitoid wasp Leptopilina boulardi, and found that survival rates increased 3 to 30 fold within 6 generations. Resistance in all three species involves a large increase in the number of the circulating hemocytes that kill parasitoids. However, the different species achieve this in different ways, with D. melanogaster moving sessile hemocytes into circulation while the other species simply produce more cells. Therefore, the convergent evolution of the immune phenotype has different developmental bases. These changes are costly, as resistant populations of all three species had greatly reduced larval survival. In all three species resistance is only costly when food is in short supply, and resistance was rapidly lost from D. melanogaster populations when food is restricted. Furthermore, evolving resistance to L. boulardi resulted in cross-resistance against other parasitoids. Therefore, whether a population evolves resistance will depend on ecological conditions including food availability and the presence of different parasite species.
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