Trial reportPloS one2017
Behavioral intervention to reduce opioid overdose among high-risk persons with opioid use disorder: A pilot randomized controlled trial.
Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02093559 (Repeated-dose Brief Intervention to Reduce Overdose and Risk Behaviors Among Naloxone Recipients), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Repeated-dose Brief Intervention to Reduce Overdose and Risk Behaviors Among Naloxone Recipients
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Pooled it
- Evidence for state, community and systems-level prevention strategies to address the opioid crisis.Drug and alcohol dependence · 2019Pooled it
- Collaborative care intervention for risky opioid use among primary care patients: The STOP randomized clinical trial.Addiction (Abingdon, England) · 2026Trial
- A randomized clinical trial of the effects of brief versus extended opioid overdose education on naloxone utilization outcomes by individuals with opioid use disorder.Drug and alcohol dependence · 2022Trial
- Effectiveness of Extended Screening and Brief Intervention (X-SBI) on Substance Misuse and Related Outcomes in Correctional Settings.Indian journal of psychological medicine · 2025Article
- Peer Intervention to Link Overdose Survivors to Treatment (PILOT): Protocol for a Multisite, Randomized Controlled Trial Conducted Within the National Institute on Drug Abuse Clinical Trials Network.JMIR research protocols · 2024Article
- Fentanyl harm reduction strategies among Latinx communities in the United States: a scoping review.Harm reduction journal · 2024Article
- Subthreshold opioid use disorder prevention (STOP) trial: a cluster randomized clinical trial: study design and methods.Addiction science & clinical practice · 2023Article
- Economic Evaluation of Extended-Release Buprenorphine for Persons With Opioid Use Disorder.JAMA network open · 2023Article
- The POP (Permanent Supportive Housing Overdose Prevention) Study: protocol for a hybrid type 3 stepped-wedge cluster randomized controlled trial.Implementation science : IS · 2023Article
- Article
- "There's No Heroin Around Anymore. It's All Fentanyl." Adaptation of an Opioid Overdose Prevention Counseling Approach to Address Fentanyl Overdose: Formative Study.JMIR formative research · 2022Article
- Using Mindfulness-Based Cognitive Therapy to Prevent Suicide among High Suicide Risk Patients who also Misuse Opioids: A Preliminary Probe of Feasibility and Effectiveness.International journal of mental health and addiction · 2022Article
- Development of opioid rapid response system: Protocol for a randomized controlled trial.Contemporary clinical trials · 2022Article
- Latent Classes of Polysubstance Use and Associations with HIV Risk and Structural Vulnerabilities among Cisgender Women Who Engage in Street-Based Transactional Sex in Baltimore City.International journal of environmental research and public health · 2022Article
- The impact of access to addiction specialist on attitudes, beliefs and hospital-based opioid use disorder related care: A survey of hospitalist physicians.Substance abuse · 2022Article
- Direct-Care Staff Perceptions of Patient Engagement and Treatment Planning in Detox.The journal of behavioral health services & research · 2021Article
- Age-based preferences for risk communication in the fentanyl era: 'A lot of people keep seeing other people die and that's not enough for them'.Addiction (Abingdon, England) · 2021Article
- Diet and companionship modulate pain via a serotonergic mechanism.Scientific reports · 2021Article
- A descriptive analysis of concurrent alcohol and substance use among patients living with HIV/HCV co-infection.Social work in health care · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe United States is amidst an opioid epidemic, including synthetic opioids that may result in rapid death, leaving minimal opportunity for bystander rescue. We pilot tested a behavioral intervention to reduce the occurrence of opioid overdose among opioid dependent persons at high-risk for subsequent overdose. MATERIALS AND
methodsWe conducted a single-blinded randomized-controlled trial of a repeated dose motivational interviewing intervention (REBOOT) to reduce overdose versus treatment as usual, defined as information and referrals, over 16 months at the San Francisco Department of Public Health from 2014-2016. Participants were 18-65 years of age, had opioid use disorder by Structured Clinical Interview, active opioid use, opioid overdose within 5 years, and prior receipt of naloxone kits. The intervention was administered at months 0, 4, 8, and 12, preceded by the assessment which was also administered at month 16. Dual primary outcomes were any overdose event and number of events, collected by computer-assisted personal interview, as well as any fatal overdose events per vital records.
resultsA total of 78 persons were screened and 63 enrolled. Mean age was 43 years, 67% were born male, 65% White, 17% African-American, and 14% Latino. Ninety-two percent of visits and 93% of counseling sessions were completed. At baseline, 33.3% of participants had experienced an overdose in the past four months, with a similar mean number of overdoses in both arms (p = 0.95); 29% overdosed during follow-up. By intention-to-treat, participants assigned to REBOOT were less likely to experience any overdose (incidence rate ratio [IRR] 0.62 [95%CI 0.41-0.92, p = 0.019) and experienced fewer overdose events (IRR 0.46, 95%CI 0.24-0.90, p = 0.023), findings that were robust to sensitivity analyses. There were no differences between arms in days of opioid use, substance use treatment, or naloxone carriage.
conclusionsREBOOT reduced the occurrence of any opioid overdose and the number of overdoses.
trial registrationclinicaltrials.gov NCT02093559.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.