Evidence map›Paper›PMID 29048966›Full record

Trial reportAmerican journal of public health2017

Text Messaging for Improving Antiretroviral Therapy Adherence: No Effects After 1 Year in a Randomized Controlled Trial Among Adolescents and Young Adults.

Sebastian Linnemayr, Haijing Huang, Jill Luoto, Andrew Kambugu, Harsha Thirumurthy, Jessica E Haberer, Glenn Wagner, Barbara Mukasa

3 registry-linked trialsOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 66 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 17 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00830622 nacompletednot on this map

A Targeted Cell Phone Intervention to Improve Patient Access to Care and Drug Adherence in Patients Taking Antiretroviral (ARV) Medications in Kenya

TypeinterventionalSponsorUniversity of ManitobaRan2007 to 2010Enrolled536ConditionsHIV, AIDS, HIV InfectionsArmsCell Phone Intervention
NCT05131165 nacompletednot on this mapstarted 2021, after this paper: background citation

INcentives and ReMINDers to Improve Long-term Medication Adherence

TypeinterventionalSponsorRANDRan2021 to 2023Enrolled166ConditionsHIV/AIDSArmsDaily Text Messages, Incentivization based on timely ART adherence
NCT06949774 narecruitingnot on this mapstarted 2025, after this paper: background citation

INcentives and ReMINDers to Improve Long-term Medication Adherence

TypeinterventionalSponsorRANDRan2025 to 2029Enrolled550ConditionsHIV/AIDS, Medication Adherence, HabitsArmsDaily Text Messages, Incentivization based on timely ART adherence
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 17 syntheses or guidelines pooled it, 131 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sebastian LinnemayrSebastian Linnemayr, Jill Luoto, and Glenn Wagner are with the RAND Corporation, Santa Monica, CA. Haijing Huang is with the Pardee RAND Graduate School, Santa Monica. Andrew Kambugu is with Infectious Diseases Institute and Makerere University, Kampala, Uganda. Harsha Thirumurthy is with Department of Health Policy and Management and Gillings School of Global Public Health at the University of North Carolina at Chapel Hill. Jessica E. Haberer is with Massachusetts General Hospital Center for Global Health and Harvard Medical School, Boston, MA. Barbara Mukasa is with Mildmay Uganda, Kampala.
Haijing HuangSebastian Linnemayr, Jill Luoto, and Glenn Wagner are with the RAND Corporation, Santa Monica, CA. Haijing Huang is with the Pardee RAND Graduate School, Santa Monica. Andrew Kambugu is with Infectious Diseases Institute and Makerere University, Kampala, Uganda. Harsha Thirumurthy is with Department of Health Policy and Management and Gillings School of Global Public Health at the University of North Carolina at Chapel Hill. Jessica E. Haberer is with Massachusetts General Hospital Center for Global Health and Harvard Medical School, Boston, MA. Barbara Mukasa is with Mildmay Uganda, Kampala.
Jill LuotoSebastian Linnemayr, Jill Luoto, and Glenn Wagner are with the RAND Corporation, Santa Monica, CA. Haijing Huang is with the Pardee RAND Graduate School, Santa Monica. Andrew Kambugu is with Infectious Diseases Institute and Makerere University, Kampala, Uganda. Harsha Thirumurthy is with Department of Health Policy and Management and Gillings School of Global Public Health at the University of North Carolina at Chapel Hill. Jessica E. Haberer is with Massachusetts General Hospital Center for Global Health and Harvard Medical School, Boston, MA. Barbara Mukasa is with Mildmay Uganda, Kampala.
Andrew KambuguSebastian Linnemayr, Jill Luoto, and Glenn Wagner are with the RAND Corporation, Santa Monica, CA. Haijing Huang is with the Pardee RAND Graduate School, Santa Monica. Andrew Kambugu is with Infectious Diseases Institute and Makerere University, Kampala, Uganda. Harsha Thirumurthy is with Department of Health Policy and Management and Gillings School of Global Public Health at the University of North Carolina at Chapel Hill. Jessica E. Haberer is with Massachusetts General Hospital Center for Global Health and Harvard Medical School, Boston, MA. Barbara Mukasa is with Mildmay Uganda, Kampala.
Harsha ThirumurthySebastian Linnemayr, Jill Luoto, and Glenn Wagner are with the RAND Corporation, Santa Monica, CA. Haijing Huang is with the Pardee RAND Graduate School, Santa Monica. Andrew Kambugu is with Infectious Diseases Institute and Makerere University, Kampala, Uganda. Harsha Thirumurthy is with Department of Health Policy and Management and Gillings School of Global Public Health at the University of North Carolina at Chapel Hill. Jessica E. Haberer is with Massachusetts General Hospital Center for Global Health and Harvard Medical School, Boston, MA. Barbara Mukasa is with Mildmay Uganda, Kampala.
Jessica E HabererSebastian Linnemayr, Jill Luoto, and Glenn Wagner are with the RAND Corporation, Santa Monica, CA. Haijing Huang is with the Pardee RAND Graduate School, Santa Monica. Andrew Kambugu is with Infectious Diseases Institute and Makerere University, Kampala, Uganda. Harsha Thirumurthy is with Department of Health Policy and Management and Gillings School of Global Public Health at the University of North Carolina at Chapel Hill. Jessica E. Haberer is with Massachusetts General Hospital Center for Global Health and Harvard Medical School, Boston, MA. Barbara Mukasa is with Mildmay Uganda, Kampala.
Glenn WagnerSebastian Linnemayr, Jill Luoto, and Glenn Wagner are with the RAND Corporation, Santa Monica, CA. Haijing Huang is with the Pardee RAND Graduate School, Santa Monica. Andrew Kambugu is with Infectious Diseases Institute and Makerere University, Kampala, Uganda. Harsha Thirumurthy is with Department of Health Policy and Management and Gillings School of Global Public Health at the University of North Carolina at Chapel Hill. Jessica E. Haberer is with Massachusetts General Hospital Center for Global Health and Harvard Medical School, Boston, MA. Barbara Mukasa is with Mildmay Uganda, Kampala.
Barbara MukasaSebastian Linnemayr, Jill Luoto, and Glenn Wagner are with the RAND Corporation, Santa Monica, CA. Haijing Huang is with the Pardee RAND Graduate School, Santa Monica. Andrew Kambugu is with Infectious Diseases Institute and Makerere University, Kampala, Uganda. Harsha Thirumurthy is with Department of Health Policy and Management and Gillings School of Global Public Health at the University of North Carolina at Chapel Hill. Jessica E. Haberer is with Massachusetts General Hospital Center for Global Health and Harvard Medical School, Boston, MA. Barbara Mukasa is with Mildmay Uganda, Kampala.
Frederick S. Pardee RAND Graduate School · US

Funding

Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Improving Drug Adherence Among Adolescents in Uganda using SMS RemindersR01HD074925 · NICHD · RAND CORPORATION · PI LINNEMAYR, SEBASTIAN · 2013 to 2017
$2.3M
NICHD NIH HHS P2C HD050924NICHD NIH HHS R01 HD074925
6 · The paper itself

Abstract

objectivesTo assess the effectiveness of Short Message Service (SMS) reminder messages on antiretroviral and cotrimoxazole prophylaxis adherence among HIV-positive youths as well as the relative effectiveness of SMS with and without a response option.

methodsEligible HIV-positive patients aged 15 to 22 years at 2 HIV clinics in Kampala, Uganda, participated in a year-long parallel individual-randomized controlled trial and were assigned in a 1-to-1-to-1 ratio to a weekly SMS message group, weekly SMS message with response option group, or a usual-care control group.

resultsWe enrolled 332 participants. Electronically measured mean adherence was 67% in the control group, 64% in the 1-way SMS group (95% confidence interval [CI] = 0.77, 1.14), and 61% in the 2-way SMS group (95% CI = 0.75, 1.12) in an intent-to-treat analysis. Results for secondary outcomes and complete-case analysis were similarly statistically insignificant across groups.

conclusionsDespite previous evidence that interventions using SMS reminders can promote antiretroviral therapy adherence, this study shows that they are not always effective in achieving behavior change. More research is needed to find out for whom, and under what conditions, they can be beneficial.

trial registrationClinicalTrials.gov identifier: NCT00830622.

Indexed as

Medication AdherenceReminder SystemsText MessagingAdolescentAIDS-Related Opportunistic InfectionsAnti-Bacterial AgentsAnti-HIV AgentsFemaleHIV SeropositivityHumansIntention to Treat AnalysisMaleOutcome Assessment, Health CareTrimethoprim, Sulfamethoxazole Drug CombinationUgandaYoung AdultAnti-Bacterial AgentsAnti-HIV AgentsTrimethoprim, Sulfamethoxazole Drug Combination

Identifiers

PMID29048966
PMCPMC5678388
OpenAlexW2766986383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.