SynthesisSocial cognitive and affective neuroscience2017
Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies.
Synthesis in Social cognitive and affective neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06945926 (The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery：Two-Stage Designs for Phase II Clinical Trials), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery：Two-Stage Designs for Phase II Clinical Trials
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- The effect of intranasal oxytocin on neural response to facial emotions in healthy adults as measured by functional MRI: A systematic review.Psychiatry research. Neuroimaging · 2018Pooled it
- Intranasal oxytocin modulates brain activity during emotional processing in children with treatment resistant conduct problems.Scientific reports · 2025Trial
- Effects of single- and multiple-dose oxytocin treatment on amygdala low-frequency BOLD fluctuations and BOLD spectral dynamics in autism.Translational psychiatry · 2022Trial
- Neural effects of oxytocin and mimicry in frontotemporal dementia: A randomized crossover study.Neurology · 2020Trial
- Oxytocin treatment attenuates amygdala activity in autism: a treatment-mechanism study with long-term follow-up.Translational psychiatry · 2020Trial
- Oxytocin facilitates valence-dependent valuation of social evaluation of the self.Communications biology · 2020Trial
- Oxytocin induces long-lasting adaptations within amygdala circuitry in autism: a treatment-mechanism study with randomized placebo-controlled design.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Effects of oxytocin administration and conditioned oxytocin on brain activity: An fMRI study.PloS one · 2020Trial
- Article
- Oxytocin: a neglected hormone in pituitary disease - From function to the diagnosis of a deficiency, resulting clinical relevance, and potential treatment options in endocrinology.Archives of endocrinology and metabolism · 2025Review
- Effects of systemic oxytocin receptor activation and blockade on risky decision making in female and male rats.Behavioral neuroscience · 2025Article
- Salivary oxytocin and amygdalar alterations in functional neurological disorders.Brain communications · 2025Article
- Psychophysiology of facial emotion recognition in psychopathy dimensions and oxytocin's role: A scoping review.PloS one · 2025Article
- Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency.Nature reviews. Endocrinology · 2024Review
- Hypothalamus and Post-Traumatic Stress Disorder: A Review.Brain sciences · 2023Review
- Article
- Effect of Intranasal Oxytocin on Resting-state Effective Connectivity in Schizophrenia.Schizophrenia bulletin · 2022Article
- Progress in Personalized Psychiatric Therapy with the Example of Using Intranasal Oxytocin in PTSD Treatment.Journal of personalized medicine · 2022Review
- Exploring gene-culture coevolution in humans by inferring neuroendophenotypes: A case study of the oxytocin receptor gene and cultural tightness.Genes, brain, and behavior · 2022Article
- The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin.Schizophrenia research. Cognition · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypothalamic peptide oxytocin (OT) is crucial in social adaptation and used to treat emotional and social deficits. Here, we conducted a systematic, quantitative meta-analysis of functional-MRI studies intranasally administering OT (IN-OT) to uncover neural substrates underlying the IN-OT effects and to elucidate differential IN-OT effects between healthy and clinical populations. Meta-analyses were conducted on 66 IN-OT fMRI studies, stratified by psychopathology, valence and sex. IN-OT increased bilateral amygdala, caudate head, and superior temporal activity in healthy individuals and increased dorsal anterior cingulate activity in patients. Moreover, IN-OT decreased amygdala activity in both patients and healthy individuals but did so to a greater degree in patients than healthy individuals. The OT-increased amygdala activity was only found on the negative social and affective processes, whereas the OT-decreased amygdala activity was mainly contributed by contrasts on negative-valenced processes. IN-OT increased parahippocampal activity and decreased amygdala activity during negative socio-affective processing. During positive socio-affective processes, IN-OT increased caudate head activity. This study indicates convergent neural substrates and the underlying neuropsychological mechanisms for IN-OT effects on social and affective processes. The common and different effects of IN-OT on patients and healthy individuals and the modulation of OT effects by valence have critical implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.