ArticleJournal of experimental botany2017
Phytosiderophores determine thresholds for iron and zinc accumulation in biofortified rice endosperm while inhibiting the accumulation of cadmium.
Article in Journal of experimental botany, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 99 citations in OpenAlex.
- Transcriptomic and physiological analyses revealed nicotianamine enhances wheat tolerance to excess manganese.iScience · 2025Article
- Intercropping with Gramineous Plants in Nutrient Solutions as a Tool to Optimize the Use of Iron inPlants (Basel, Switzerland) · 2025Article
- Engineering of nicotianamine synthesis enhances cadmium mobility in plants and results in higher seed cadmium concentrations.The Plant journal : for cell and molecular biology · 2025Article
- Functional nutritional rice: current progresses and future prospects.Frontiers in plant science · 2024Review
- Nicotianamine: A Key Player in Metal Homeostasis and Hyperaccumulation in Plants.International journal of molecular sciences · 2023Review
- Endophytes in Agriculture: Potential to Improve Yields and Tolerances of Agricultural Crops.Microorganisms · 2023Review
- Concomitant Activation ofInternational journal of molecular sciences · 2023Article
- Rice biofortification: breeding and genomic approaches for genetic enhancement of grain zinc and iron contents.Frontiers in plant science · 2023Review
- Genetic Approaches for Iron and Zinc Biofortification and Arsenic Decrease in Oryza sativa L. Grains.Biological trace element research · 2022Review
- The Role of Sulfur in Agronomic Biofortification with Essential Micronutrients.Plants (Basel, Switzerland) · 2022Review
- Biofortification-A Frontier Novel Approach to Enrich Micronutrients in Field Crops to Encounter the Nutritional Security.Molecules (Basel, Switzerland) · 2022Review
- A tale of two metals: Biofortification of rice grains with iron and zinc.Frontiers in plant science · 2022Review
- Biofortification and bioavailability of Zn, Fe and Se in wheat: present status and future prospects.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
- Improvement of nutrient use efficiency in rice: current toolbox and future perspectives.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- Potential Implications of Interactions between Fe and S on Cereal Fe Biofortification.International journal of molecular sciences · 2020Review
- High-frequency random DNA insertions upon co-delivery of CRISPR-Cas9 ribonucleoprotein and selectable marker plasmid in rice.Scientific reports · 2019Article
- The ratio of phytosiderophores nicotianamine to deoxymugenic acid controls metal homeostasis in rice.Planta · 2019Article
- Iron Biofortification of Staple Crops: Lessons and Challenges in Plant Genetics.Plant & cell physiology · 2019Review
- Environmental and Health Implications of the Correlation Between Arsenic and Zinc Levels in Rice from an Arsenic-Rich Zone in Cambodia.Journal of health & pollution · 2019Article
- Biotechnological Approaches for Generating Zinc-Enriched Crops to Combat Malnutrition.Nutrients · 2019Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nicotianamine (NA) and 2'-deoxymugenic acid (DMA) are metal-chelating ligands that promote the accumulation of metals in rice endosperm, but it is unclear how these phytosiderophores regulate the levels of different metals and limit their accumulation. In this study, transgenic rice plants producing high levels of NA and DMA accumulated up to 4-fold more iron (Fe) and 2-fold more zinc (Zn) in the endosperm compared with wild-type plants. The distribution of Fe and Zn in vegetative tissues suggested that both metals are sequestered as a buffering mechanism to avoid overloading the seeds. The buffering mechanism involves the modulation of genes encoding metal transporters in the roots and aboveground vegetative tissues. As well as accumulating more Fe and Zn, the endosperm of the transgenic plants accumulated less cadmium (Cd), suggesting that higher levels of Fe and Zn competitively inhibit Cd accumulation. Our data show that although there is a strict upper limit for Fe (~22.5 µg g-1 dry weight) and Zn (~84 µg g-1 dry weight) accumulation in the endosperm, the careful selection of strategies to increase endosperm loading with essential minerals can also limit the accumulation of toxic metals such as Cd, thus further increasing the nutritional value of rice.
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