Evidence map›Paper›PMID 29048555›Full record

ArticleGigaScience2017

An architecture for genomics analysis in a clinical setting using Galaxy and Docker.

W Digan, H Countouris, M Barritault, D Baudoin, P Laurent-Puig, H Blons, A Burgun, B Rance

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in GigaScience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

W DiganUniversity Hospital Georges Pompidou, HEGP, Department of Medical Informatics, AP-HP, INSERM, Centre de Recherche des Cordeliers, UMRS 1138, Université Sorbonne Paris Cité, University Paris-Descartes, Paris, France.
H CountourisUniversity Hospital Georges Pompidou, HEGP, Department of Medical Informatics, AP-HP, INSERM, Centre de Recherche des Cordeliers, UMRS 1138, Université Sorbonne Paris Cité, University Paris-Descartes, Paris, France.
M BarritaultUniversity Hospital Georges Pompidou, HEGP, Department of Biochemistry, Pharmacogenetics and Molecular Oncology, AP-HP, Paris, France, University Paris-Descartes.
D BaudoinUniversity Hospital Georges Pompidou, HEGP, Department of Medical Informatics, AP-HP, INSERM, Centre de Recherche des Cordeliers, UMRS 1138, Université Sorbonne Paris Cité, University Paris-Descartes, Paris, France.
P Laurent-PuigINSERM UMR-S1147, CNRS SNC 5014, Université Sorbonne Paris Cité, Paris, France.
H BlonsUniversity Hospital Georges Pompidou, HEGP, Department of Biochemistry, Pharmacogenetics and Molecular Oncology, AP-HP, Paris, France, University Paris-Descartes.
A BurgunUniversity Hospital Georges Pompidou, HEGP, Department of Medical Informatics, AP-HP, INSERM, Centre de Recherche des Cordeliers, UMRS 1138, Université Sorbonne Paris Cité, University Paris-Descartes, Paris, France.
B RanceUniversity Hospital Georges Pompidou, HEGP, Department of Medical Informatics, AP-HP, INSERM, Centre de Recherche des Cordeliers, UMRS 1138, Université Sorbonne Paris Cité, University Paris-Descartes, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Next-generation sequencing is used on a daily basis to perform molecular analysis to determine subtypes of disease (e.g., in cancer) and to assist in the selection of the optimal treatment. Clinical bioinformatics handles the manipulation of the data generated by the sequencer, from the generation to the analysis and interpretation. Reproducibility and traceability are crucial issues in a clinical setting. We have designed an approach based on Docker container technology and Galaxy, the popular bioinformatics analysis support open-source software. Our solution simplifies the deployment of a small-size analytical platform and simplifies the process for the clinician. From the technical point of view, the tools embedded in the platform are isolated and versioned through Docker images. Along the Galaxy platform, we also introduce the AnalysisManager, a solution that allows single-click analysis for biologists and leverages standardized bioinformatics application programming interfaces. We added a Shiny/R interactive environment to ease the visualization of the outputs. The platform relies on containers and ensures the data traceability by recording analytical actions and by associating inputs and outputs of the tools to EDAM ontology through ReGaTe. The source code is freely available on Github at https://github.com/CARPEM/GalaxyDocker.

Indexed as

Genome, HumanGenetic TestingGenomicsHumansReproducibility of ResultsSoftwareDockerGalaxyReGaTEreproducibility

Identifiers

PMID29048555
PMCPMC5691353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.