ArticleGigaScience2017
Panax ginseng genome examination for ginsenoside biosynthesis.
Article in GigaScience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
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Who cites it
101 citing papers in PubMed, 225 citations in OpenAlex.
- Chromosome-level genome of wild-simulated Panax ginseng identifies SNP markers for germplasm and medicinal quality evaluation.Journal of advanced research · 2026Article
- Subgenome-Resolved Analysis and Regulatory Divergence of UDP-Glycosyltransferases in AllotetraploidGenes · 2026Article
- Insights into Enzymes Involved in the Biosynthesis of Protopanaxadiol-Type Ginsenosides inACS omega · 2026Review
- Comprehensive Identification and Integrated Analysis of theLife (Basel, Switzerland) · 2026Article
- Cytogenomic profiling ofJournal of ginseng research · 2026Article
- Genome-Wide Identification and Expression Analysis ofBiology · 2026Article
- UV-C irradiation enhances the antimicrobial and Anti-Inflammatory bioactivity of ginseng oil.Scientific reports · 2026Article
- Disease-induced changes inFrontiers in microbiology · 2026Article
- Comparative transcriptome and physiological analyses unveil differential responses ofFrontiers in plant science · 2026Article
- Genome-wide analysis and functional characterization ofFrontiers in plant science · 2026Article
- Comparative mitochondrial genome analysis of Panax ginseng reveals structural variation and genetic diversity.Scientific reports · 2025Article
- Comparative genomic analysis of Artemisia argyi reveals asymmetric expansion of terpene synthases and conservation of artemisinin biosynthesis.The Plant journal : for cell and molecular biology · 2025Article
- Jasmonates mediate increased levels of ginsenosides in Panax Quinquefolius cambial meristematic cell cultures.BMC plant biology · 2025Article
- Immunomodulatory Activities of Emerging Rare Ginsenosides F1, Rg5, Rk1, Rh1, and Rg2: From Molecular Mechanisms to Therapeutic Applications.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Sustainable Production of Ginsenosides: Advances in Biosynthesis and Metabolic Engineering.Plants (Basel, Switzerland) · 2025Review
- Multi-omics dissection of metabolic and transcriptional regulation underlying fruit maturation in Panax ginseng.BMC plant biology · 2025Article
- Genome-Wide Identification of UGT Gene Family and Functional Analysis ofInternational journal of molecular sciences · 2025Article
- Chromosome-level genome assembly of an important ethnic medicinal plant Callicarpa nudiflora.Scientific data · 2025Article
- Screening and Application of DNA Markers for Novel Quality Consistency Evaluation inInternational journal of molecular sciences · 2025Article
- Decoding the mystery: AI-assisted bioinformatics and functional genomics technologies in medicinal plants.Frontiers in plant science · 2025Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
33 authors at 7 institutions in 2 countries.
Funding
Abstract
Ginseng, which contains ginsenosides as bioactive compounds, has been regarded as an important traditional medicine for several millennia. However, the genetic background of ginseng remains poorly understood, partly because of the plant's large and complex genome composition. We report the entire genome sequence of Panax ginseng using next-generation sequencing. The 3.5-Gb nucleotide sequence contains more than 60% repeats and encodes 42 006 predicted genes. Twenty-two transcriptome datasets and mass spectrometry images of ginseng roots were adopted to precisely quantify the functional genes. Thirty-one genes were identified to be involved in the mevalonic acid pathway. Eight of these genes were annotated as 3-hydroxy-3-methylglutaryl-CoA reductases, which displayed diverse structures and expression characteristics. A total of 225 UDP-glycosyltransferases (UGTs) were identified, and these UGTs accounted for one of the largest gene families of ginseng. Tandem repeats contributed to the duplication and divergence of UGTs. Molecular modeling of UGTs in the 71st, 74th, and 94th families revealed a regiospecific conserved motif located at the N-terminus. Molecular docking predicted that this motif captures ginsenoside precursors. The ginseng genome represents a valuable resource for understanding and improving the breeding, cultivation, and synthesis biology of this key herb.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.