ArticleJournal of perinatology : official journal of the California Perinatal Association2018
Association of unit-wide oxygen saturation target on incidence of pulmonary hypertension in very low birthweight premature infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Patent Ductus Arteriosus and Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Bayesian Meta-Analysis.JAMA network open · 2023Pooled it
- Oxygen Targets in Neonatal Pulmonary Hypertension: Individualized, "Precision-Medicine" Approach.Clinics in perinatology · 2024Review
- Pediatric Pulmonary Hypertension: Definitions, Mechanisms, Diagnosis, and Treatment.Comprehensive Physiology · 2021Article
- Oxygen therapy in preterm infants with pulmonary hypertension.Seminars in fetal & neonatal medicine · 2020Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAssess the effect of increasing pulse oximetry targets on incidence of pulmonary hypertension in very low birthweight premature infants. STUDY
designRetrospective cohort study comparing pulmonary hypertension incidence among three cohorts of premature infants exposed to varying oxygen saturation targets (Cohort 1: n=459, 1 May 2009 to 30 April 2011, 85-94%; Cohort 2: n=474, 1 May 2011 to 31 May 2013, 88-94%; Cohort 3: n=387, 1 June 2013 to 31 May 2015, 90-95%). Subjects had birth weight <1500 g and gestational age 23-32 weeks. Chi-square, Kruskall-Wallis and Anderson-Darling tests were used, as well as multivariable logistic regression.
resultsIncidence of pulmonary hypertension declined with higher oxygen saturation targets (19.0% Cohort 1, 7.9% Cohort 2, 9.6% Cohort 3, P<0.001). Other parameters were largely not different between cohorts though rates of chorioamnionitis and prenatal steroids increased and oxygen use, inhaled nitric oxide use, necrotizing enterocolitis and patent ductus arteriosus ligation decreased over time.
conclusionHigher oxygen saturation targets for very low-birthweight premature infants were associated with reduced rates of pulmonary hypertension in this retrospective cohort study.
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