Evidence map›Paper›PMID 29048297›Full record

ArticleEmerging infectious diseases2017

Polyclonal Pulmonary Tuberculosis Infections and Risk for Multidrug Resistance, Lima, Peru.

Ruvandhi R Nathavitharana, Cynthia X Shi, Leonid Chindelevitch, Roger Calderon, Zibiao Zhang, Jerome T Galea, Carmen Contreras, Rosa Yataco, Leonid Lecca, Mercedes C Becerra and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. A Novel Technique to CharacterizebioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Ruvandhi R Nathavitharana
Cynthia X Shi
Leonid Chindelevitch
Roger Calderon
Zibiao Zhang
Jerome T Galea
Carmen Contreras
Rosa Yataco
Leonid Lecca
Mercedes C Becerra
Megan B Murray
Ted Cohen
EsSALUD · PEImperial College London · GBBeth Israel Deaconess Medical Center · USHarvard University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Using Coincidence Analysis to Investigate Factors Affecting PrEP Initiation and Continuation in Southern ending the Epidemic CountiesP30MH062294 · NIMH · YALE UNIVERSITY · PI E. Jennifer Edelman · 2001 to 2026
$48.5M
Understanding and controlling antibiotic resistanceU54GM088558 · NIGMS · HARVARD SCHOOL OF PUBLIC HEALTH · PI LIPSITCH, MARC · 2009 to 2018
$26.4M
INTERDISCIPLINARY HIV PREVENTION TRAINING PROGRAMT32MH020031 · NIMH · YALE UNIVERSITY · PI Trace S Kershaw · 1999 to 2026
$12.1M
Epidemiology of multidrug-resistant tuberculosis in PeruU01AI057786 · NIAID · HARVARD MEDICAL SCHOOL · PI BECERRA, MERCEDES C · 2009 to 2010
$1.2M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS P30 AI060354NIAID NIH HHS U01 AI057786NIGMS NIH HHS U54 GM088558NIMH NIH HHS P30 MH062294NIMH NIH HHS T32 MH020031Wellcome Trust
6 · The paper itself

Abstract

Because within-host Mycobacterium tuberculosis diversity complicates diagnosis and treatment of tuberculosis (TB), we measured diversity prevalence and associated factors among 3,098 pulmonary TB patients in Lima, Peru. The 161 patients with polyclonal infection were more likely than the 115 with clonal or the 2,822 with simple infections to have multidrug-resistant TB.

Indexed as

Tuberculosis, Multidrug-ResistantAdolescentAdultCohort StudiesFemaleGenetic VariationHumansMaleMiddle AgedMycobacterium tuberculosisPeruPrevalenceRiskTuberculosis, PulmonaryYoung Adultantimicrobial resistancebacteriaclassifier of tandem repeatsClassTRdrug susceptibility testingMIRU-VNTRmultidrug-resistant TBmycobacterial interspersed repetitive units–variable number of tandem repeatsMycobacterium tuberculosisPerupolyclonal infectionstrain diversityTBtuberculosistuberculosis and other mycobacteria

Identifiers

PMID29048297
PMCPMC5652442
OpenAlexW2761144537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.