Evidence map›Paper›PMID 29048285›Full record

ArticleEmerging infectious diseases2017

High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium.

Yan Guo, Adam D Tomich, Christi L McElheny, Vaughn S Cooper, Amelia Tait-Kamradt, Minggui Wang, Fupin Hu, Louis B Rice, Nicolas Sluis-Cremer, Yohei Doi

Abstract read
In one paragraph

Article in Emerging infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Antimicrobial Susceptibility Testing for Enterococci.Journal of clinical microbiology · 2022
    Review
  3. Article
  4. Tuberculosis challenges: Resistance, co-infection, diagnosis, and treatment.European journal of microbiology & immunology · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. New microbiological aspects of fosfomycin.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2019
    Review
  11. Article
  12. Article
  13. Molecules that Inhibit Bacterial Resistance Enzymes.Molecules (Basel, Switzerland) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan Guo
Adam D Tomich
Christi L McElheny
Vaughn S Cooper
Amelia Tait-Kamradt
Minggui Wang
Fupin Hu
Louis B Rice
Nicolas Sluis-Cremer
Yohei Doi

Funding

Colistin-resistant Acinetobacter baumanniiR01AI104895 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI, ERNST, ROBERT K · 2014 to 2024
$4.2M
Mechanisms and implications of fosfomycin resistance in Escherichia coliR21AI123747 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI · 2016 to 2017
$417k
NIAID NIH HHS R01 AI104895NIAID NIH HHS R21 AI123747
6 · The paper itself

Abstract

Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays.

Indexed as

Alkyl and Aryl TransferasesAmino Acid SubstitutionAnti-Bacterial AgentsBacterial ProteinsDrug Resistance, BacterialEnterococcus faeciumFosfomycinGram-Positive Bacterial InfectionsHumansMicrobial Sensitivity TestsMutationPennsylvaniaVancomycinAlkyl and Aryl TransferasesAnti-Bacterial AgentsBacterial ProteinsFosfomycinUDP-N-acetylglucosamine 1-carboxyvinyltransferaseVancomycinantimicrobial resistancebacteriaEnterococcus faeciumfosfomycinfosfomycin resistanceMurAUDP-N-acetylglucosamine enolpyruvyl transferasevancomycinvancomycin resistancevancomycin-resistant enterococci

Identifiers

PMID29048285
PMCPMC5652432

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.