ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2017
The role of a palliative care intervention in moderating the relationship between depression and survival among individuals with advanced cancer.
Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Development of the Health Coaching Quality Index: A Proposed Method for Evaluating Health Coaching Interventions.International journal of behavioral medicine · 2026Pooled it
- Psychiatric Comorbidities and Outcomes in Palliative and End-of-Life Care: A Systematic Review.Journal of pain and symptom management · 2023Pooled it
- Effect of an Early Palliative Care Telehealth Intervention vs Usual Care on Patients With Heart Failure: The ENABLE CHF-PC Randomized Clinical Trial.JAMA internal medicine · 2020Trial
- Depression, performance status, and discontinued treatment mediate an association of curability belief with prognosis in advanced cancer patients.Scientific reports · 2024Article
- The Effectiveness and Feasibility of Palliative Care via Video Telemedicine for Patients with Advanced Cancer: A Nonrandomized Prospective Clinical Trial Comparing Combination of Telemedicine and in-Person Care with in-Person Care Alone.Palliative medicine reports · 2024Article
- Patient & Caregiver Experiences: Qualitative Study Comparison Before and After Implementation of Early Palliative Care for Advanced Colorectal Cancer.The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres · 2023Article
- Impact of interprofessional collaborative practice in palliative care on outcomes for advanced cancer inpatients in a resource-limited setting.BMC palliative care · 2022Article
- Enhanced supportive care for advanced cancer patients: study protocol for a randomized controlled trial.BMC nursing · 2022Article
- Optimal Supportive Care for Patients With Metastatic Breast Cancer According to Their Disease Progression Phase.JCO oncology practice · 2021Review
- Article
- Cultural Adaptation and Open Pilot of Meaning-Centered Psychotherapy for Puerto Rican Patients with Advanced Cancer.Science journal of education · 2020Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveRandomized controlled trials (RCTs) of early palliative care interventions in advanced cancer have positively impacted patient survival, yet the mechanisms remain unknown. This secondary analysis of 2 RCTs assessed whether an early palliative care intervention moderates the relationship between depressive symptoms and survival.
methodThe relationships among mood, survival, and early palliative care intervention were studied among 529 advanced cancer patients who participated in 2 RCTs. The first (N = 322) compared intervention versus usual care. The second (N = 207) compared early versus delayed intervention (12 weeks after enrollment). The interventions included an in-person consultation, weekly nurse coach-facilitated phone sessions, and monthly follow-up. Mood was measured using the Center for Epidemiologic Studies-Depression (CES-D) scale. Cox proportional hazard analyses were used to examine the effects of baseline CES-D scores, the intervention, and their interaction on mortality risk while controlling for demographic variables, cancer site, and illness severity.
resultsThe combined sample was 56% male (M = 64.7 years). Higher baseline CES-D scores were significantly associated with greater mortality risk (hazard ratio [HR] = 1.042, 95% confidence interval [CI] [1.017, 1.067], p = .001). However, participants with higher CES-D scores who received the intervention had a lower mortality risk (HR = .963, CI [0.933, 0.993], p = .018) even when controlling for demographics, cancer site, and illness-related variables.
conclusionThis study is the first to demonstrate that patients with advanced cancer who also have depressive symptoms benefit the most from early palliative care. Future research should be devoted to exploring the mechanisms responsible for these relationships. (PsycINFO Database Record
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