Evidence map›Paper›PMID 29048129›Full record

ArticleBritish journal of haematology2017

Realgar nanoparticles versus ATO arsenic compounds induce in vitro and in vivo activity against multiple myeloma.

Danka Cholujova, Zdenka Bujnakova, Erika Dutkova, Teru Hideshima, Richard W Groen, Constantine S Mitsiades, Paul G Richardson, David M Dorfman, Peter Balaz, Kenneth C Anderson and 1 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in British journal of haematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Arsenic Nanoparticles Trigger Apoptosis viaInternational journal of molecular sciences · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Arsenic in medicine: past, present and future.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Frontiers in oncology · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Danka CholujovaCancer Research Institute, Biomedical Research Center SAS, Bratislava, Slovakia.
Zdenka BujnakovaInstitute of Geotechnics SAS, Košice, Slovakia.
Erika DutkovaInstitute of Geotechnics SAS, Košice, Slovakia.
Teru HideshimaDepartment of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Boston, MA, USA.
Richard W GroenDepartment of Hematology, VU University Medical Center, Amsterdam, the Netherlands.
Constantine S MitsiadesDepartment of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Boston, MA, USA.
Paul G RichardsonDepartment of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-7426-8865
David M DorfmanDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Peter BalazInstitute of Geotechnics SAS, Košice, Slovakia.
Kenneth C AndersonDepartment of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Boston, MA, USA.
Jana JakubikovaCancer Research Institute, Biomedical Research Center SAS, Bratislava, Slovakia.ORCID 0000-0003-2593-569X
Harvard University · USInstitute of Geotechnics of the Slovak Academy of Sciences · SKAmsterdam UMC Location Vrije Universiteit Amsterdam · NLBrigham and Women's Hospital · USCancer Research Institute of the Slovak Academy of Sciences · SK

Funding

Trageting the Multiple Myeloma EpigenomeP50CA100707 · NCI · DANA-FARBER CANCER INSTITUTE · PI ANDERSON, KENNETH C. · 2003 to 2023
$45.0M
Targeting Myeloma Cell-Host Bone Marrow InteractionsP01CA078378 · NCI · DANA-FARBER CANCER INSTITUTE · PI KUFE, DONALD W. · 1998 to 2014
$26.2M
Role of Cytokines in Myeloma PathogenesisR01CA050947 · NCI · DANA-FARBER CANCER INSTITUTE · PI ANDERSON, KENNETH C., MITSIADES, CONSTANTINE S. · 1991 to 2018
$5.1M
NCI NIH HHS P01 CA078378NCI NIH HHS P50 CA100707NCI NIH HHS R01 CA050947
6 · The paper itself

Abstract

Multiple myeloma (MM), a B cell malignancy characterized by clonal proliferation of plasma cells in the bone marrow, remains incurable despite the use of novel and conventional therapies. In this study, we demonstrated MM cell cytotoxicity triggered by realgar (REA; As

Indexed as

AnimalsAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsApoptosisArsenicalsArsenic TrioxideCell CycleCell DeathCell Line, TumorDose-Response Relationship, DrugDrug Delivery SystemsHumansMice, SCIDMolecular Targeted TherapyMultiple MyelomaNanoparticlesAntineoplastic AgentsArsenicalsarsenic disulfideArsenic TrioxideOxidesPHB2 protein, humanProhibitinsSulfidesarsenic compoundsATOmultiple myelomarealgar nanoparticlesstem-like side population

Identifiers

PMID29048129
PMCPMC5705577
OpenAlexW2766757380

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.