Evidence map›Paper›PMID 29047229›Full record

ArticleAging cell2018

Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene-induced lung tumors in aged mice.

Neha Parikh, Ryan L Shuck, Mihai Gagea, Lanlan Shen, Lawrence A Donehower

Abstract read
In one paragraph

Article in Aging cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
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  8. Review
  9. Article
  10. Review
  11. Balancing DNA repair to prevent ageing and cancer.Experimental cell research · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. Toxicity of TiOInternational journal of molecular sciences · 2020
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Neha ParikhDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA.
Ryan L ShuckDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA.
Mihai GageaDepartment of Veterinary Medicine and Surgery, UT MD Anderson Cancer Center, Houston, TX, 77030, USA.
Lanlan ShenChildren's Nutrition Research Center, Houston, TX, 77030, USA.
Lawrence A DonehowerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA.

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
TRANSGENIC MOUSE MODELS TO STUDY OVARIAN FUNCTIONU54HD007495 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI SMITH, CAROLYN L · 1998 to 2013
$19.9M
GROWTH AND DIFFERENTIATION IN EUKARYOTEST32HD007495 · NICHD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KINTNER, CHRISTOPHER ROBERT · 1995 to 2009
$1.6M
The effects of Age on Cancer Signaling Pathways in MiceR21AG035365 · NIA · BAYLOR COLLEGE OF MEDICINE · PI DONEHOWER, LAWRENCE A. · 2010 to 2011
$340k
TRANSGENIC ANIMAL--COREP30HD007495 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI GLASSER, STANLEY R · 1985 to 1997
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NCI NIH HHS P30 CA125123NIA NIH HHS R21 AG035365NICHD NIH HHS P30 HD007495NICHD NIH HHS T32 HD007495NICHD NIH HHS U54 HD007495NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

Aging is often accompanied by a dramatic increase in cancer susceptibility. To gain insights into how aging affects tumor susceptibility, we generated a conditional mouse model in which oncogenic Kras

Indexed as

AgingAnimalsCell ProliferationCell Transformation, NeoplasticDisease Models, AnimalGenes, rasInflammationLung NeoplasmsMiceMutationSignal TransductionagingcancerinflammationKrasp53tumor microenvironment

Identifiers

PMID29047229
PMCPMC5771401

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.