ArticleCNS neuroscience & therapeutics2017
Expression of aromatase in the rostral ventromedial medulla and its role in the regulation of visceral pain.
Article in CNS neuroscience & therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- Neural circuits regulating visceral pain.Communications biology · 2024Review
- Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance.The Journal of clinical investigation · 2023Article
- Estrogen metabolites increase nociceptor hyperactivity in a mouse model of uterine pain.JCI insight · 2022Article
- The chronification mechanism of orofacial inflammatory pain: Facilitation by GPER1 and microglia in the rostral ventral medulla.Frontiers in molecular neuroscience · 2022Article
- G protein-coupled estrogen receptor in the rostral ventromedial medulla contributes to the chronification of postoperative pain.CNS neuroscience & therapeutics · 2021Article
- Non-reproductive Functions of Aromatase in the Central Nervous System Under Physiological and Pathological Conditions.Cellular and molecular neurobiology · 2019Review
- Expression of aromatase in the rostral ventromedial medulla and its role in the regulation of visceral pain.CNS neuroscience & therapeutics · 2017Article
- Estrogen modulation of visceral pain.Journal of Zhejiang University. Science. BReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsEstrogens are known to exert a wide spectrum of actions on brain functions including modulation of pain. Besides the circulating estrogens produced mainly by the ovaries, many brain regions are also capable of de novo synthesizing estrogens, which may exert important modulatory effects on neuronal functions. This study was aimed to test the hypothesis that aromatase, the enzyme that catalyzes the conversion of testosterone to estradiols, may be distributed in the rostral ventromedial medulla (RVM), where it may impact on visceral pain. METHODS AND
resultsAdult female rats were treated with cyclophosphamide (CPM, 50 mg/kg, ip, once every 3 days) or saline. At approximately day 10 following the 3rd injection, CPM-treated rats exhibited colorectal hyperalgesia as they showed significantly greater abdominal withdrawal responses (AWR) to graded colorectal distension (CRD, 0-100 mm Hg) than the saline group. Immunofluorescent staining and Western blot assay revealed that CPM-induced colorectal hyperalgesia was associated with significantly increased expression of aromatase and phosphorylated μ-type opioid receptor (pMOR) and decreased expression of total MOR in the RVM. Intracisternal application of aromatase inhibitors, fadrozole, and letrozole reversed CPM-induced colorectal hyperalgesia and restored pMOR and MOR expression in the RVM.
conclusionsOur observations confirmed the expression of aromatase in the RVM, a pivotal brain region in descending modulation of pain and opioid analgesia. The results support the hypothesis that locally produced estrogens in the RVM may be involved in the maintenance of chronic visceral hyperalgesia and the downstream signaling may involve phosphorylation of MOR.
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