Evidence map›Paper›PMID 29047012›Full record

ArticleGeroScience2017

Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys.

Tara L Moore, Bethany Bowley, Penny Shultz, Samantha Calderazzo, Eli Shobin, Ronald J Killiany, Douglas L Rosene, Mark B Moss

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. Parallel patterns of cognitive aging in marmosets and macaques.bioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Age-Related Learning and Working Memory Impairment in the Common Marmoset.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tara L MooreDepartment of Anatomy & Neurobiology, Boston University School of Medicine, 72 E. Concord Street, L-1004, Boston, MA, 02118, USA. tlmoore@bu.edu.ORCID 0000-0003-3869-3837
Bethany BowleyDepartment of Anatomy & Neurobiology, Boston University School of Medicine, 72 E. Concord Street, L-1004, Boston, MA, 02118, USA.
Penny ShultzDepartment of Anatomy & Neurobiology, Boston University School of Medicine, 72 E. Concord Street, L-1004, Boston, MA, 02118, USA.
Samantha CalderazzoDepartment of Anatomy & Neurobiology, Boston University School of Medicine, 72 E. Concord Street, L-1004, Boston, MA, 02118, USA.
Eli ShobinDepartment of Anatomy & Neurobiology, Boston University School of Medicine, 72 E. Concord Street, L-1004, Boston, MA, 02118, USA.
Ronald J KillianyDepartment of Anatomy & Neurobiology, Boston University School of Medicine, 72 E. Concord Street, L-1004, Boston, MA, 02118, USA.
Douglas L RoseneDepartment of Anatomy & Neurobiology, Boston University School of Medicine, 72 E. Concord Street, L-1004, Boston, MA, 02118, USA.
Mark B MossDepartment of Anatomy & Neurobiology, Boston University School of Medicine, 72 E. Concord Street, L-1004, Boston, MA, 02118, USA.
Boston University · US

Funding

Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey BrainR01AG043640 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 2013 to 2017
$3.0M
The effect of curcumin on age-related cognitive decline in the rhesus monkeyR01AG043478 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MOSS, MARK BARRY · 2013 to 2017
$2.9M
NIA NIH HHS P30 AG013846NIA NIH HHS R01AG043478NIA NIH HHS R01 AG043640NIA NIH HHS R01AG043640
6 · The paper itself

Abstract

Studies of both humans and non-human primates have demonstrated that aging is typically characterized by a decline in cognition that can occur as early as the fifth decade of life. Age-related changes in working memory are particularly evident and mediated, in part, by the prefrontal cortex, an area known to evidence age-related changes in myelin that is attributed to inflammation. In recent years, several nutraceuticals, including curcumin, by virtue of their anti-inflammatory and antioxidant effects, have received considerable attention as potential treatments for age-related cognitive decline and inflammation. Accordingly, we assessed for the first time in a non-human primate model of normal aging the efficacy of dietary intervention using the natural phenol curcumin to ameliorate the effects of aging on spatial working and recognition memory. Results revealed that monkeys receiving daily administration of curcumin over 14-18 months demonstrated a greater improvement in performance on repeated administration of a task of spatial working memory compared to monkeys that received a control substance.

Indexed as

Age FactorsAnimalsCognitionCurcuminDisease Models, AnimalDrug Administration ScheduleFemaleHaplorhiniHumansMaleMemory, Short-TermMiddle AgedRandom AllocationReference ValuesSex FactorsSpatial MemoryCurcuminAgingCognitionCurcuminMemoryRhesus monkey

Identifiers

PMID29047012
PMCPMC5745216
OpenAlexW2766451797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.