Evidence map›Paper›PMID 29046942›Full record

ArticleEuropean journal of clinical pharmacology2018

Antidepressants and the risk of arrhythmia in elderly affected by a previous cardiovascular disease: a real-life investigation from Italy.

A Biffi, F Rea, L Scotti, A Mugelli, E Lucenteforte, A Bettiol, A Chinellato, G Onder, C Vitale, N Agabiti and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of clinical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Tako Tsubo and Treatment of Comorbid Depression: A Reflection is Needed - Author's reply.Clinical practice and epidemiology in mental health : CP & EMH · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

A BiffiLaboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy. a.biffi14@campus.unimib.it.
F ReaLaboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.
L ScottiLaboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.
A MugelliDepartment of Neurosciences, Psychology, Drug Research and Children's Health, University of Florence, Florence, Italy.
E LucenteforteDepartment of Neurosciences, Psychology, Drug Research and Children's Health, University of Florence, Florence, Italy.
A BettiolDepartment of Neurosciences, Psychology, Drug Research and Children's Health, University of Florence, Florence, Italy.
A ChinellatoTreviso Local Health Unit, Treviso, Italy.
G OnderDepartment of Geriatrics, Neurosciences and Orthopaedics, A. Gemelli University Hospital, Università Cattolica del Sacro Cuore, Rome, Italy.
C VitaleDepartment of Medical Sciences, IRCCS San Raffaele Pisana, Rome, Italy.
N AgabitiDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
G TrifiròDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
G RobertoEpidemiology Unit, Regional Agency for Healthcare Services of Tuscany, Florence, Italy.
G CorraoLaboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.
Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE)
University of Milano-Bicocca · ITUniversity of Florence · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Messina · ITAgenzia Regionale di Sanità della Toscana · ITAULSS 2 Marca Trevigiana · ITIRCCS Ospedale San Raffaele · IT

Funding

AIFA project FARM9LBBBL
6 · The paper itself

Abstract

purposeThe study aimed to fill existing knowledge gaps on the safety of antidepressant drugs (ADs) by estimating the risk of hospitalization for arrhythmia associated with use of selective serotonin reuptake inhibitors (SSRIs) and newer atypical ADs (NAAs) among elderly with previous cardiovascular (CV) events.

methodsThe cohort was composed by 199,569 individuals aged ≥ 65 years from five Italian healthcare territorial units who were discharged for cardiovascular outcomes in the years 2008-2010. The 17,277 patients who experienced hospital admission for arrhythmia during follow-up were included as cases. Odds of current ADs use among cases (i.e., 14 days before hospital admission) was compared with (i) odds of current use of 1:5 matched controls (between-patients case-control) and with (ii) odds of previous use during 1:5 matched control periods (within-patient case-crossover). The risk of arrhythmia associated with ADs current use was modelled fitting a conditional logistic regression. A set of sensitivity analyses was performed to account for sources of systematic uncertainty.

resultsCurrent users of SSRIs and NAAs were at increased risk of arrhythmia with case-control odds ratios (OR) of 1.37 (95% confidence interval, CI 1.18 to 1.58) and 1.41 (1.16 to 1.71) and case-crossover OR of 1.48 (1.20 to 1.81) and 1.72 (1.31 to 2.27). An increased risk of arrhythmia was associated with current use of trazodone (NAA) consistently in case-control and case-crossover designs.

conclusionsEvidence that current use of SSRIs and NAAs is associated to an increased risk of arrhythmia among elderly with CV disease was consistently supplied by two observational approaches.

Indexed as

AgedAntidepressive AgentsArrhythmias, CardiacCardiovascular DiseasesCohort StudiesComorbidityFemaleHospitalizationHumansItalyMaleOdds RatioRisk FactorsAntidepressive AgentsAntidepressantsArrhythmiaCase-crossover studyDatabaseNested case-control studyNewer atypical antidepressantsSelective serotonin reuptake inhibitorsTricyclic antidepressants

Identifiers

PMID29046942
OpenAlexW2767161998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.