Evidence map›Paper›PMID 29046940›Full record

ArticleVirchows Archiv : an international journal of pathology2018

Gastric cancer: immunohistochemical classification of molecular subtypes and their association with clinicopathological characteristics.

Eva-Maria Birkman, Naziha Mansuri, Samu Kurki, Annika Ålgars, Minnamaija Lintunen, Raija Ristamäki, Jari Sundström, Olli Carpén

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Eva-Maria BirkmanDepartment of Pathology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland. emabir@utu.fi.ORCID http://orcid.org/0000-0002-6238-8480
Naziha MansuriDepartment of Pathology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
Samu KurkiAuria Biobank, University of Turku and Turku University Hospital, Kiinamyllynkatu 8, 20520, Turku, Finland.
Annika ÅlgarsDepartment of Oncology, Turku University Hospital, Hämeentie 11, 20520, Turku, Finland.
Minnamaija LintunenDepartment of Pathology, Turku University Hospital, Kiinamyllynkatu 10, 20520, Turku, Finland.
Raija RistamäkiDepartment of Oncology, Turku University Hospital, Hämeentie 11, 20520, Turku, Finland.
Jari SundströmDepartment of Pathology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
Olli CarpénDepartment of Pathology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
University of Turku · FITurku University Hospital · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer is traditionally divided into intestinal and diffuse histological subtypes, but recent molecular analyses have led to novel classification proposals based on genomic alterations. While the intestinal- and diffuse-type tumours are distinguishable from each other at the molecular level, intestinal-type tumours have more diverse molecular profile. The technology required for comprehensive molecular analysis is expensive and not applicable for routine clinical diagnostics. In this study, we have used immunohistochemistry and in situ hybridisation in molecular classification of gastric adenocarcinomas with an emphasis on the intestinal subtype. A tissue microarray consisting of 244 gastric adenocarcinomas was constructed, and the tumours were divided into four subgroups based on the presence of Epstein-Barr virus, TP53 aberrations and microsatellite instability. The intestinal- and diffuse-type tumours were separately examined. The distribution of EGFR and HER2 gene amplifications was studied in the intestinal-type tumours. Epstein-Barr virus positive intestinal-type tumours were more common in male patients (p = 0.035) and most often found in the gastric corpus (p = 0.011). The majority of the intestinal-type tumours with TP53 aberrations were proximally located (p = 0.010). All tumours with microsatellite instability showed intestinal-type histology (p = 0.017) and were associated with increased overall survival both in the univariate (p = 0.040) and multivariate analysis (p = 0.015). In conclusion, this study shows that gastric adenocarcinomas can be classified into biologically and clinically different subgroups by using a simple method also applicable for clinical diagnostics.

Indexed as

ImmunohistochemistryAdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorFemaleHumansIn Situ HybridizationIntestinal NeoplasmsMalePathology, ClinicalStomach NeoplasmsBiomarkers, TumorGastric cancerImmunohistochemistryIn situ hybridisationMolecular classification

Identifiers

PMID29046940
PMCPMC5886993
OpenAlexW2765961964

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.