ArticleHereditary cancer in clinical practice2017
Colorectal cancer incidence in
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Hereditary cancer in clinical practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06708429 (Impact of Immune-surveillance on the Development of Colorectal Cancer in Patients With Lynch Syndrome), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
5.0field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Immune-surveillance on the Development of Colorectal Cancer in Patients With Lynch Syndrome
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Testing strategies for Lynch syndrome in people with endometrial cancer: systematic reviews and economic evaluation.Health technology assessment (Winchester, England) · 2021Pooled it
- European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender.The British journal of surgery · 2021Guideline
- Guideline
- Routes to colorectal cancer in Lynch syndrome: a decade of molecular and clinical insights converging on Schrödinger's cat.Familial cancer · 2026Review
- Transitioning from the Prospective Lynch Syndrome Database (PLSD) to the International Lynch Syndrome Database (ILSD).Familial cancer · 2026Article
- Factors Associated with Adherence to Recommended Colorectal Surveillance Intervals in Lynch Syndrome.Cancers · 2026Article
- Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database.The British journal of surgery · 2025Article
- Circulating metabolome landscape in Lynch syndrome.Cancer & metabolism · 2024Article
- Dominantly inherited micro-satellite instable cancer - the four Lynch syndromes - an EHTG, PLSD position statement.Hereditary cancer in clinical practice · 2023Review
- Evaluating colonoscopy screening intervals in patients with Lynch syndrome from a large Canadian registry.Journal of the National Cancer Institute · 2023Article
- The "scope" of colorectal cancer screening in Lynch syndrome: is there an optimal interval?Journal of the National Cancer Institute · 2023Article
- Review
- Lynch syndrome: from detection to treatment.Frontiers in oncology · 2023Review
- Review
- Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium.Hereditary cancer in clinical practice · 2022Article
- Cost-effectiveness of population-wide genomic screening for Lynch syndrome in the United States.Genetics in medicine : official journal of the American College of Medical Genetics · 2022Article
- Progress Report: New insights into the prevention of CRC by colonoscopic surveillance in Lynch syndrome.Familial cancer · 2022Review
- Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model.Gastroenterology · 2021Article
- Review
- No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants inJournal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 20 institutions in 10 countries.
Toni SeppäläDepartment of Surgery, Helsinki University Hospital and University of Helsinki, Post Box 340, 00029 Helsinki, Finland.
Kirsi PylvänäinenFinnish Lynch Syndrome registry, Helsinki University Hospital, Helsinki, Finland.
Dafydd Gareth EvansManchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Heikki JärvinenDepartment of Surgery, Helsinki University Hospital and University of Helsinki, Post Box 340, 00029 Helsinki, Finland.
Laura Renkonen-SinisaloDepartment of Surgery, Helsinki University Hospital and University of Helsinki, Post Box 340, 00029 Helsinki, Finland.
Inge BernsteinDanish HNPCC Register, Hvidovre University Hospital, Copenhagen, Denmark.
Elke Holinski-FederMedizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Ziemssenstr. 1, 80336 Munich, Germany.
Paola SalaUnit of Hereditary Digestive Tract Tumors IRCCS Istituto Nazionale Tumori Milan, Milan, Italy.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Finlay MacraeColorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia.
Ignacio BlancoHereditary Cancer Program. Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Rolf SijmonsDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Jacqueline JeffriesInstitute of Medical Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN UK.
Hans VasenDepartment of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, the Netherlands.
John BurnInstitute of Human Genetics, Newcastle upon Tyne, UK.
Sigve NakkenDepartment of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Oslo, Norway.
Eivind HovigDepartment of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Oslo, Norway.
Einar Andreas RødlandDepartment of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Oslo, Norway.
Kukatharmini TharmaratnamDepartment of Mathematics, University of Oslo, Blindern, Oslo, Norway.
Wouter H de Vos Tot Nederveen CappelDepartment of Gastroenterology and Hepatology, Isala Clinics, Zwolle, the Netherlands.
James HillDepartment of Surgery, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Juul WijnenDepartment of Clinical Genetics and Department of Human Genetics Leiden University Medical Centre, Leiden, The Netherlands.
Mark JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC Australia.
Maurizio GenuardiMedical Genetics Unit, University of Florence, Florence, Italy.
Kate GreenManchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Fiona LallooManchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Lone SundeDanish HNPCC Register, Hvidovre University Hospital, Copenhagen, Denmark.
Miriam MintsDepartment of Women's and Children's health, Division of Obstetrics and Gynecology, Karolinska Institutet, Karolinska University Hospital, Solna S171 76, Stockholm, Sweden.
Lucio BertarioUnit of Hereditary Digestive Tract Tumors IRCCS Istituto Nazionale Tumori Milan, Milan, Italy.
Marta PinedaHereditary Cancer Program. Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Matilde NavarroHereditary Cancer Program. Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Monika MorakMedizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Ziemssenstr. 1, 80336 Munich, Germany.
Ian M FraylingInstitute of Medical Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN UK.
John-Paul PlazzerColorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia.
Julian R SampsonInstitute of Medical Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN UK.
Gabriel CapellaHereditary Cancer Program. Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Gabriela MösleinCenter for Hereditary Tumors, HELIOS University Hospital Wuppertal, University Witten/Herdecke, Witten, Germany.
Jukka-Pekka MecklinDepartment of Education and Science, Central Finland Health Care District, Jyväskylä, Finland.
Pål MøllerResearch Group Inherited Cancer, The Norwegian Radium Hospital, Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Mallorca Group
Oslo University Hospital · NOCardiff University · GBFondazione IRCCS Istituto Nazionale dei Tumori · ITHelsinki University Hospital · FIHvidovre Hospital · DKInstitut Català d'Oncologia · ESInstitut d'Investigació Biomédica de Bellvitge · ESKarolinska Institutet · SELeiden University · NLMedical Genetics Center · DEThe Royal Melbourne Hospital · AUUniversity of Helsinki · FIUniversity of Manchester · GBIsala · NLManchester Academic Health Science Centre · GBUniversity Medical Center Groningen · NLUniversity of Eastern Finland · FIUniversity of Florence · ITUniversity of Melbourne · AUUniversity of Oslo · NO
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have previously reported a high incidence of colorectal cancer (CRC) in carriers of pathogenic
methodsThe cohort included Finnish carriers enrolled in 3-yearly colonoscopy (
resultsCumulative CRC incidences in carriers of
conclusionsThe hypothesis that the high incidence of CRC in
Indexed as
Colorectal cancerHereditary non-polyposis colorectal cancerLynch syndromeMicrosatellite instability
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT06708429ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.