Evidence map›Paper›PMID 29046674›Full record

ReviewFrontiers in immunology2017

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development.

Stefan H E Kaufmann, Hazel M Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H M Ottenhoff, Brij Patel, Danielle Roordink, François Spertini and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Review
  3. In silico design ofHeliyon · 2024
    Article
  4. Review
  5. Article
  6. Mouse Models forPathogens (Basel, Switzerland) · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Identification ofVaccines · 2021
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  17. Article
  18. Review
  19. Article
  20. Frontiers in immunology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 5 countries.

Stefan H E KaufmannDepartment of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.
Hazel M DockrellImmunology and Infection Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Nick DragerTuberculosis Vaccine Initiative (TBVI), Lelystad, Netherlands.
Mei Mei HoBacteriology Division, MHRA-NIBSC, Potters Bar, United Kingdom.
Helen McShaneUniversity of Oxford, Oxford, United Kingdom.
Olivier NeyrollesInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Tom H M OttenhoffLeiden University Medical Center, Leiden, Netherlands.
Brij PatelRegExcel Consulting Ltd, Surrey, United Kingdom.
Danielle RoordinkTuberculosis Vaccine Initiative (TBVI), Lelystad, Netherlands.
François SpertiniCentre Hospital Universitaire Vaudois, Lausanne, Switzerland.
Steffen StengerUniversity Hospital of Ulm, Ulm, Germany.
Jelle TholeTuberculosis Vaccine Initiative (TBVI), Lelystad, Netherlands.
Frank A W VerreckBiomedical Primate Research Centre, Rijswijk, Netherlands.
Ann WilliamsPublic Health England, London, United Kingdom.
TBVAC2020 Consortium
TuBerculosis Vaccine Initiative · NLBiomedical Primate Research Centre · NLHexcel (United Kingdom) · GBInstitut de Pharmacologie et de Biologie Structurale · FRLeiden University Medical Center · NLLondon School of Hygiene & Tropical Medicine · GBMax Planck Institute for Infection Biology · DEPotters Bar Community Hospital · GBPublic Health England · GBUniversity Hospital of Lausanne · CHUniversity Hospital Ulm · DEUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The project builds on previous collaborations from 1998 onwards funded through the EC framework programs FP5, FP6, and FP7. It has succeeded in attracting new partners from outstanding laboratories from all over the world, now totaling 40 institutions. Next to the development of novel vaccines, TB biomarker development is also considered an important asset to facilitate rational vaccine selection and development. In addition, TBVAC2020 offers portfolio management that provides selection criteria for entry, gating, and priority settings of novel vaccines at an early developmental stage. The TBVAC2020 consortium coordinated by TBVI facilitates collaboration and early data sharing between partners with the common aim of working toward the development of an effective TB vaccine. Close links with funders and other consortia with shared interests further contribute to this goal.

Indexed as

bacille Calmette–Guérinbiomarkerclinical trialdiscoveryportfolio managementtuberculosisvaccination

Identifiers

PMID29046674
PMCPMC5632681
OpenAlexW2763033987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.