Evidence map›Paper›PMID 29046648›Full record

ArticleFrontiers in psychology2017

The Relationships among Tryptophan, Kynurenine, Indoleamine 2,3-Dioxygenase, Depression, and Neuropsychological Performance.

Knut A Hestad, Knut Engedal, Jon E Whist, Per G Farup

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  4. BrainFrontiers in immunology · 2021
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  11. Interaction of the Vagus Nerve and Serotonin in the Gut-Brain Axis.International journal of molecular sciences · 2025
    Review
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  13. Sex- and suicide-specific alterations in the kynurenine pathway in the anterior cingulate cortex in major depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Knut A HestadDepartment of Research, Innlandet Hospital Trust, Brumunddal, Norway.
Knut EngedalNorwegian Center for Aging and Health, Vestfold Health Trust, Tønsberg, Norway.
Jon E WhistDepartment of Medical Biochemistry, Innlandet Hospital Trust, Brumunddal, Norway.
Per G FarupDepartment of Research, Innlandet Hospital Trust, Brumunddal, Norway.
Innlandet Hospital Trust · NONorwegian University of Science and Technology · NOSykehuset i Vestfold · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been suggested that the metabolic enzyme indoleamine 2,3-dioxygenase (IDO) is a biological mediator of inflammation related to the psychopathology of depression, with a Kynurenine (KYN) increase in the Tryptophan (TRP) metabolic pathway, resulting in reduced Serotonin. In this study, we examined KYN, TRP, and the ratio of KYN to TRP concentrations × 10

Indexed as

depressionIDOindoleamine 2,3-dioxygenasekynurenineneuropsychologytryptophan

Identifiers

PMID29046648
PMCPMC5632654
OpenAlexW2764041992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.