Evidence map›Paper›PMID 29046608›Full record

ArticleMolecular vision2017

Elucidating the molecular basis of PPCD: Effects of decreased ZEB1 expression on corneal endothelial cell function.

Marina Zakharevich, Jaffer M Kattan, Judy L Chen, Benjamin R Lin, Aleck E Cervantes, Doug D Chung, Ricardo F Frausto, Anthony J Aldave

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Molecular vision, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marina ZakharevichStein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Jaffer M KattanStein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Judy L ChenStein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Benjamin R LinStein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Aleck E CervantesStein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Doug D ChungStein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Ricardo F FraustoStein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Anthony J AldaveStein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
Identification and Characterization of the Genetic Basis of PPCDR01EY022082 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALDAVE, ANTHONY JOHN · 2013 to 2017
$1.9M
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY022082
6 · The paper itself

Abstract

purposeTo investigate the functional role that the

methodsA human corneal endothelial cell line (HCEnC-21T) was transfected with siRNA targeting

results

conclusionsThe corneal endothelium in PPCD3 is characterized by morphologic, anatomic, and molecular features that are more consistent with an epithelial-like rather than an endothelial-like phenotype. Although these characteristics have been well documented, we demonstrate for the first time that susceptibility to UV-induced apoptosis and cell barrier function are significantly altered in the setting of reduced

Indexed as

Antibiotics, AntineoplasticApoptosisBlotting, WesternCaspase 3Cell LineCell MovementCell ProliferationCorneal Dystrophies, HereditaryDoxorubicinElectric ImpedanceEndothelium, CornealGene Expression RegulationGene Knockdown TechniquesHumansRNA, MessengerRNA, Small InterferingAntibiotics, AntineoplasticCaspase 3DoxorubicinRNA, MessengerRNA, Small InterferingZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1

Identifiers

PMID29046608
PMCPMC5644665
OpenAlexW2765310590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.