ArticleThe Journal of veterinary medical science2017
Hypoxia increases glucose transporter 1 expression in bovine corpus luteum at the early luteal stage.
Article in The Journal of veterinary medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Dynamic Regulation of HIF1α and Oxygen-Sensing Factors in Cyclic Bovine Corpus Luteum and During LPS Challenge.Animals : an open access journal from MDPI · 2025Article
- Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways.Scientific reports · 2021Article
- Multiple roles of hypoxia in bovine corpus luteum.The Journal of reproduction and development · 2020Review
- Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1.Frontiers in physiology · 2020Review
- Low Oxygen Levels Induce Early Luteinization Associated Changes in Bovine Granulosa Cells.Frontiers in physiology · 2018Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major role of the corpus luteum (CL) is to produce progesterone (P4). The CL has immature vasculature shortly after ovulation, suggesting it exists under hypoxic conditions. Hypoxia-inducible factor-1 (HIF1) induces the expression of glucose transporter 1 (GLUT1). To clarify the physiological roles of GLUT1 in bovine CL, we examined GLUT1 mRNA expression in the CL under hypoxic conditions by quantitative RT-PCR. We also measured the effects of glucose (0-25 mM) and GLUT1 inhibitors (cytochalasin B, STF-31) on P4 production in bovine luteal cells. GLUT1 mRNA expression in bovine CL was higher at the early luteal stage compared to the other later stages. Hypoxia (3% O
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