Evidence map›Paper›PMID 29046488›Full record

ReviewJournal of atherosclerosis and thrombosis2018

Principles and Applications of Rabbit Models for Atherosclerosis Research.

Jianglin Fan, Yajie Chen, Haizhao Yan, Manabu Niimi, Yanli Wang, Jingyan Liang

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of atherosclerosis and thrombosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 87 citations in OpenAlex.

  1. Review
  2. Article
  3. Is Cooler Safer and More Advantageous? A Feasibility Study in Rabbits.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2026
    Article
  4. 3D cryoimaging of cell-mediated cholesterol crystal clearance in human atherosclerotic lesions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Use of Rabbit Models to Study Atherosclerosis.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jianglin FanDepartment of Molecular Pathology, Faculty of Medicine, Graduate School of Medical Sciences, University of Yamanashi.
Yajie ChenDepartment of Molecular Pathology, Faculty of Medicine, Graduate School of Medical Sciences, University of Yamanashi.
Haizhao YanDepartment of Molecular Pathology, Faculty of Medicine, Graduate School of Medical Sciences, University of Yamanashi.
Manabu NiimiDepartment of Molecular Pathology, Faculty of Medicine, Graduate School of Medical Sciences, University of Yamanashi.
Yanli WangDepartment of Pathology, Xi'an Medical University.
Jingyan LiangResearch Center for Vascular Biology, Yangzhou University School of Medicine.
University of Yamanashi · JPXi'an Medical University · CNYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rabbits are one of the most used experimental animals for biomedical research, particularly as a bioreactor for the production of antibodies. However, many unique features of the rabbit have also made it as an excellent species for examining a number of aspects of human diseases such as atherosclerosis. Rabbits are phylogenetically closer to humans than rodents, in addition to their relatively proper size, tame disposition, and ease of use and maintenance in the laboratory facility. Due to their short life spans, short gestation periods, high numbers of progeny, low cost (compared with other large animals) and availability of genomics and proteomics, rabbits usually serve to bridge the gap between smaller rodents (mice and rats) and larger animals, such as dogs, pigs and monkeys, and play an important role in many translational research activities such as pre-clinical testing of drugs and diagnostic methods for patients. The principle of using rabbits rather than other animals as an experimental model is very simple: rabbits should be used for research, such as translational research, that is difficult to accomplish with other species. Recently, rabbit genome sequencing and transcriptomic profiling of atherosclerosis have been successfully completed, which has paved a new way for researchers to use this model in the future. In this review, we provide an overview of the recent progress using rabbits with specific reference to their usefulness for studying human atherosclerosis.

Indexed as

Disease Models, AnimalAnimalsAnimals, Genetically ModifiedAtherosclerosisGenomeGenomicsHumansRabbitsReproducibility of ResultsTranslational Research, BiomedicalAnimal modelsAtherosclerosisHypercholesterolemiaRabbitsTransgenic

Identifiers

PMID29046488
PMCPMC5868506
OpenAlexW2766159646

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.