Evidence map›Paper›PMID 29046407›Full record

ArticleJournal of clinical microbiology2018

An Improved Extended-Spectrum-β-Lactamase Detection Test Utilizing Aztreonam plus Clavulanate.

Gina K Thomson, Maaz Ayaz, Kelli Lutes, Kenneth S Thomson

Abstract readComparative Study
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gina K ThomsonUniversity of Louisville Hospital, Louisville, Kentucky, USA.
Maaz AyazUniversity of Louisville School of Medicine, Louisville, Kentucky, USA.
Kelli LutesUniversity of Louisville School of Medicine, Louisville, Kentucky, USA.
Kenneth S ThomsonUniversity of Louisville School of Medicine, Louisville, Kentucky, USA kenneth.thomson@louisville.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical laboratories test for extended-spectrum β-lactamases (ESBLs) for epidemiological and infection control purposes and also for the potential of cephalosporins to cause therapeutic failures. Testing can be problematic, because the CLSI does not recommend the testing of all producers of ESBLs and also falsely negative results may occur with isolates that coproduce AmpC. Boronic acid-supplemented tests can enhance ESBL detection in AmpC producers. Because aztreonam inhibits AmpCs, a study was designed to compare ESBL detection by the CLSI disk test (CLSI), a boronic acid-supplemented CLSI disk test (CLSI plus BA), and an aztreonam plus clavulanate disk test (ATM plus CA). The study tested 100 well-characterized

Indexed as

Anti-Bacterial AgentsAztreonamBacteriaBacteriological Techniquesbeta-Lactamase Inhibitorsbeta-Lactamasesbeta-Lactam ResistanceClavulanic AcidMicrobial Sensitivity TestsAnti-Bacterial AgentsAztreonambeta-Lactamase Inhibitorsbeta-LactamasesClavulanic AcidAmpCCLSIESBL

Identifiers

PMID29046407
PMCPMC5744226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.