Evidence map›Paper›PMID 29046318›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2018

Central serotonin and the control of arterial blood pressure and heart rate in infant rats: influence of sleep state and sex.

Jennifer L Magnusson, Kevin J Cummings

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jennifer L MagnussonDepartment of Biomedical Sciences, College of Veterinary Medicine, University of Missouri , Columbia, Missouri.
Kevin J CummingsDepartment of Biomedical Sciences, College of Veterinary Medicine, University of Missouri , Columbia, Missouri.ORCID 0000-0002-4100-8856
Missouri College · US

Funding

The role of central 5-HT in heart rate and blood pressure regulation during sleep in the neonatal periodF31HL136067 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI MAGNUSSON, JENNIFER LEIGH · 2017 to 2018
$44k
NHLBI NIH HHS F31 HL136067
6 · The paper itself

Abstract

Sudden infant death syndrome (SIDS) is associated with serotonin (5-HT) neuron abnormalities. There is evidence of autonomic dysfunction during sleep in infants eventually succumbing to SIDS, as well as cardiovascular collapse before death. Neonatal rodents deficient in central 5-HT display hypotension and bradycardia. We hypothesized that central 5-HT reduces cardiac vagal tone and increases sympathetic vascular tone and, given the firing pattern of 5-HT neurons, that these effects are greater in quiet sleep (QS) than in active sleep (AS). We tested these hypotheses using 2-wk-old male and female rat pups lacking tryptophan hydroxylase-2 ( TPH2

Indexed as

Arterial PressureHeart RateSleepAnimalsAnimals, NewbornAutonomic Nervous SystemBrainFemaleHeartHumansInfant, NewbornMaleRats, TransgenicRisk FactorsSerotoninSex FactorsSerotonintph2 protein, ratTryptophan Hydroxylaseautonomicblood pressurecardiovascularCNSserotonin

Identifiers

PMID29046318
PMCPMC5867675
OpenAlexW2766586350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.