Evidence map›Paper›PMID 29046311›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2018

Activity of muscle sympathetic neurons during normotensive pregnancy.

Sydney M L Schmidt, Charlotte W Usselman, Eric Martinek, Michael K Stickland, Colleen G Julian, Radha Chari, Rshmi Khurana, Sandra T Davidge, Margie H Davenport, Craig D Steinback

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Differential regulation of sympathetic neural burst frequency and amplitude throughout normal pregnancy: a longitudinal study.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  7. Posture-related changes in sympathetic baroreflex sensitivity during normal pregnancy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Article
  8. Neural control of blood pressure during pregnancy in humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020
    Review
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sydney M L SchmidtNeurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta , Edmonton, AB , Canada.
Charlotte W UsselmanNeurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta , Edmonton, AB , Canada.
Eric MartinekNeurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta , Edmonton, AB , Canada.
Michael K SticklandDivision of Pulmonary Medicine, Department of Medicine, Faculty of Medicine & Dentistry,  University of Alberta , Edmonton, AB , Canada.
Colleen G JulianDepartment of Medicine, University of Colorado Denver School of Medicine , Denver, Colorado.
Radha ChariWomen and Children's Health Research Institute, University of Alberta , Edmonton, AB , Canada.
Rshmi KhuranaWomen and Children's Health Research Institute, University of Alberta , Edmonton, AB , Canada.
Sandra T DavidgeWomen and Children's Health Research Institute, University of Alberta , Edmonton, AB , Canada.
Margie H DavenportNeurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta , Edmonton, AB , Canada.
Craig D SteinbackNeurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta , Edmonton, AB , Canada.
Women and Children’s Health Research Institute · CAUniversity of Alberta · CAUniversity of Colorado Denver · US

Funding

Effects of chronic hypoxia and AMPK activation on uteroplacental perfusion, placental metabolism and the regulation of fetal growthR01HD088590 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Colleen Glyde Julian, LORNA G. MOORE · 2016 to 2026
$4.3M
Antenatal Exposures and Non-Communicable Disease(ANDES): Building research capacity to identify and treat causes of NCD in BoliviaR21TW010797 · FIC · UNIVERSITY OF COLORADO DENVER · PI JULIAN, COLLEEN GLYDE, MOORE, LORNA G. · 2017 to 2018
$389k
FIC NIH HHS R21 TW010797NICHD NIH HHS R01 HD088590
6 · The paper itself

Abstract

In pathological populations, elevated sympathetic activity is associated with increased activity of individual sympathetic neurons. We used custom action potential detection software to analyze multiunit sympathetic activity in 18 normotensive pregnant women (third trimester; 33 ± 5 wk) and 19 nonpregnant women at rest and a subset (10 and 13, respectively) during a cold pressor challenge. Although the number of action potentials per burst and number of active amplitude-based "clusters" were not different between groups, the total number of sympathetic action potentials per minute was higher in pregnant women at rest. Individual clusters were active predominately once per burst, suggesting they represent single neurons. Action potentials occurred in closer succession in normotensive pregnant (interspike interval 36 ± 10 ms) versus nonpregnant women (50 ± 27 ms; P < 0.001) at rest. Pregnant women had a lower total peripheral resistance (11.7 ± 3.0 mmHg·l

Indexed as

Action PotentialsCase-Control StudiesCold TemperatureEvoked Potentials, MotorFemaleHumansMuscle, SkeletalPeroneal NervePregnancyRecruitment, NeurophysiologicalSympathetic Nervous SystemTime Factorsaction potentialsmicroneurographyneural recruitmentspregnancysympathetic activity

Identifiers

PMID29046311
PMCPMC5867668
OpenAlexW2766336794

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.