Evidence map›Paper›PMID 29046306›Full record

ArticleClinical and vaccine immunology : CVI2017

GI-19007, a Novel Saccharomyces cerevisiae-Based Therapeutic Vaccine against Tuberculosis.

Thomas H King, Crystal A Shanley, Zhimin Guo, Donald Bellgrau, Timothy Rodell, Synthia Furney, Marcela Henao-Tamayo, Ian M Orme

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  6. The effect of antigen dose on T cell-targeting vaccine outcome.Human vaccines & immunotherapeutics · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Thomas H KingGlobeImmune Inc., Louisville, Colorado, USA tom.king@globeimmune.com.
Crystal A ShanleyMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Zhimin GuoGlobeImmune Inc., Louisville, Colorado, USA.
Donald BellgrauGlobeImmune Inc., Louisville, Colorado, USA.
Timothy RodellGlobeImmune Inc., Louisville, Colorado, USA.
Synthia FurneyMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Marcela Henao-TamayoMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Ian M OrmeMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Colorado State University · USGlobeImmune (United States) · US

Funding

Recombinant yeast vaccines for sensitive and drug-resistant M. tuberculosisR01AI105053 · NIAID · GLOBEIMMUNE, INC. · PI DUKE, RICHARD CHATTERTON · 2013 to 2016
$4.0M
NIAID NIH HHS R01 AI105053
6 · The paper itself

Abstract

As yet, very few vaccine candidates with activity in animals against

Indexed as

Gene Transfer TechniquesAnimalsAntigens, BacterialFemaleGuinea PigsInterferon-gammaInterleukin-17LungMiceMice, Inbred C57BLMycobacterium tuberculosisPost-Exposure ProphylaxisRecombinant Fusion ProteinsSaccharomyces cerevisiaeSurvival AnalysisTreatment OutcomeAntigens, BacterialInterferon-gammaInterleukin-17Recombinant Fusion ProteinsTuberculosis VaccinesVaccines, SubunitVaccines, SyntheticBCG vaccinerecombinant yeast vaccineT cellsTh17 cellsTh1 cellstherapeutictherapeutic vaccinetuberculosis

Identifiers

PMID29046306
PMCPMC5717186
OpenAlexW2765237401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.