Trial reportThe American journal of clinical nutrition2017
Neuromodulation directed at the prefrontal cortex of subjects with obesity reduces snack food intake and hunger in a randomized trial.
2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph
Trial report in The American journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Transcranial Direct Current Stimulation (TDCS) on Food Intake and Weight Loss
Neuromodulation With Transcranial Direct Current Stimulation (tDCS) to Control Excess Weight
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- The cerebellum plays more than one role in the dysregulation of appetite: Review of structural evidence from typical and eating disorder populations.Brain and behavior · 2023Pooled it
- Reduced plasma interleukin-6 concentration after transcranial direct current stimulation to the prefrontal cortex.Behavioural brain research · 2024Trial
- Infusion of donor feces affects the gut-brain axis in humans with metabolic syndrome.Molecular metabolism · 2020Trial
- Noninvasive neuromodulation of the prefrontal cortex in young women with obesity: a randomized clinical trial.International journal of obesity (2005) · 2020Trial
- Neuromodulation of the prefrontal cortex facilitates diet-induced weight loss in midlife women: a randomized, proof-of-concept clinical trial.International journal of obesity (2005) · 2020Trial
- Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017-2025: An update) - endorsed by the European Society for Brain Stimulation (ESBS) and by the International Federation for Clinical Neurophysiology (IFCN).Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Prefrontal Structural Asymmetry Mediates Body Mass Index and Treatment Response in Major Depressive Disorder.Depression and anxiety · 2026Article
- The Neurobiology of Eating Behavior in Obesity: Mechanisms and Therapeutic Targets: A Report from the 23rd Annual Harvard Nutrition Obesity Symposium.The American journal of clinical nutrition · 2023Article
- Effects of aerobic exercise training in oxidative metabolism and mitochondrial biogenesis markers on prefrontal cortex in obese mice.BMC sports science, medicine & rehabilitation · 2022Article
- Neurobiological regulation of eating behavior: Evidence based on non-invasive brain stimulation.Reviews in endocrine & metabolic disorders · 2022Review
- The effects of Transcranial Direct Current Stimulation on food craving and food intake in individuals affected by obesity and overweight: a mini review of the magnitude of the effects.AIMS neuroscience · 2022Review
- Efficacy and acceptability of noninvasive brain stimulation interventions for weight reduction in obesity: a pilot network meta-analysis.International journal of obesity (2005) · 2021Article
- The Co-occurrence of Pediatric Obesity and ADHD: an Understanding of Shared Pathophysiology and Implications for Collaborative Management.Current obesity reports · 2020Review
- Health, pleasure, and fullness: changing mindset affects brain responses and portion size selection in adults with overweight and obesity.International journal of obesity (2005) · 2020Article
- Brain Stimulation to Modulate Food Intake and Eating Behavior.Current diabetes reports · 2019Review
- Brain stimulation for treatment of obesity: will stimulating the prefrontal cortex reduce overeating?The American journal of clinical nutrition · 2017Article
- Obesity, Appetite, and the Prefrontal Cortex.Current obesity reports · 2017Review
Corrections and comments
- Commented on by
Authors and funding
12 authors at 5 institutions in 2 countries.
Sascha HeinitzObesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ.ORCID http://orcid.org/0000-0002-5010-6183
Martin ReinhardtDepartment of Diagnostic and Interventional Radiology and.
Paolo PiaggiObesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ.
Christopher M WeiseClinic and Policlinic of Neurology, University of Leipzig, Leipzig, Germany.
Enrique DiazObesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ.
Emma J StinsonObesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ.
Colleen VentiObesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ.
Susanne B VotrubaObesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ.
Eric M WassermannBehavioral Neurology Unit, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; and.
Miguel Alonso-AlonsoLaboratory of Bariatric and Nutritional Neuroscience, Center for the Study of Nutrition Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Jonathan KrakoffObesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ.
Marci E GluckObesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ; gmarci@niddk.nih.gov.
National Institute of Diabetes and Digestive and Kidney Diseases · USBeth Israel Deaconess Medical Center · USLeipzig University · DENational Institute of Neurological Disorders and Stroke · USUniversity Hospital Leipzig · DE
Funding
Electrophysiological Probes And Treatments In Neurobehavioral DisordersZIANS002977 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI WASSERMANN, ERIC M · 2009 to 2025
$14.6MNeuronal activity and its role in adiposity and food intakeZIADK069088 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRAKOFF, JONATHAN · 2009 to 2025
$9.1MAbstract
PubMed holds no abstract for this paper.
Indexed as
Energy IntakeSnacksTranscranial Direct Current StimulationAppetiteBody Mass IndexBody WeightEatingFeeding BehaviorFemaleHumansHungerInhibition, PsychologicalMaleObesityPrefrontal CortexSelf-Controlad libitum food intakedorsolateral prefrontal cortexeating in the absence of hungerhungerneuromodulationobesitysnack food intaketranscranial direct current stimulation (tDCS)weight change
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT00739362ClinicalTrials.gov
NCT03351426ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.