ReviewCurrent neuropharmacology2018
E-cigarettes: Impact of E-Liquid Components and Device Characteristics on Nicotine Exposure.
Review in Current neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 2 syntheses or guidelines pooled it, 242 citations in OpenAlex.
- The association between self-reported vaping and the human oral microbiome: a systematic review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Pooled it
- Systemic and Salivary Cytokine Levels among Adult E-Cigarette Users: A Systematic Review and Meta Analysis.Asian Pacific journal of cancer prevention : APJCP · 2025Pooled it
- Adverse symptoms attributed to e-cigarettes over 6 months among participants of a randomized controlled trial testing nicotine free-base e-cigarettes for smoking cessation: secondary analysis of the ESTxENDS trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Trial
- Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science.Addiction biology · 2022Trial
- The effects of inhaled flavors on intravenous nicotine.Experimental and clinical psychopharmacology · 2021Trial
- Effect of Exposure to e-Cigarettes With Salt vs Free-Base Nicotine on the Appeal and Sensory Experience of Vaping: A Randomized Clinical Trial.JAMA network open · 2021Trial
- Twenty-four-hour subjective and pharmacological effects of ad-libitum electronic and combustible cigarette use among dual users.Addiction (Abingdon, England) · 2020Trial
- The Impact of E-liquid Propylene Glycol and Vegetable Glycerin Ratio on Ratings of Subjective Effects, Reinforcement Value, and Use in Current Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Trial
- Piloting a clinical laboratory method to evaluate the influence of potential modified risk tobacco products on smokers' quit-related motivation, choice, and behavior.Addictive behaviors · 2019Trial
- Differentiating e-cigarette use and dual use: the role of impulsivity.Psychopharmacology · 2026Article
- E-cigarettes and erectile dysfunction: biological mechanisms and research challenges.International journal of impotence research · 2026Review
- Influence of nicotine concentration and flavours on mouth level exposure and puffing topography among regular e-cigarette consumers in New Zealand.Scientific reports · 2026Article
- E-cigarette exposure impairs skeletal muscle mitochondrial function in male mice.Physiological reports · 2026Article
- Chemometric Analysis of Fourier Transform Infrared Spectra for the Detection of Cotinine in Fingernails of E-Cigarette Users.Molecules (Basel, Switzerland) · 2026Article
- Assessment of nicotine pharmacokinetics and abuse liability in randomized, crossover studies of Vuse Alto electronic nicotine delivery systems.Frontiers in pharmacology · 2026Article
- 'E-cigarette smoking' is a misleading term: a critical review of its use in academic literature.Internal and emergency medicine · 2025Review
- Impact of flavorants on nicotine vapor self-administration in adolescent mice: Cherry on top?The Journal of pharmacology and experimental therapeutics · 2025Article
- A Youth-Centered Digital Infographic on Vaping Risks (What's in a Vape?): Mixed Methods Study.JMIR formative research · 2025Article
- Effects of Nicotine-Free E-Cigarettes on Gastrointestinal System: A Systematic Review.Biomedicines · 2025Review
- Impact of Vaping on Hospital Outcomes in Patients With Acute Respiratory Distress Syndrome.Cureus · 2025Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundElectronic cigarette (e-cigarette) use has increased substantially in recent years. While e-cigarettes have been proposed as a potentially effective smoking cessation tool, dualuse in smokers is common and e-cigarettes are widely used by non-smokers, including youth and young-adult non-smokers. Nicotine, the primary addictive component in cigarettes, is present at varying levels in many e-liquids. E-cigarettes may lead to initiation of nicotine use in adult and youth non-smokers, re-initiation of nicotine dependence in ex-smokers or increased severity of nicotine dependence in dual-users of cigarettes and e-cigarettes. As such, there are important clinical and policy implications to understanding factors impacting nicotine exposure from e-cigarettes. However, the broad and rapidly changing range of e-liquid constituents and e-cigarette hardware which could impact nicotine exposure presents a challenge. Recent changes in regulatory oversight of e-cigarettes underscore the importance of synthesizing current knowledge on common factors which may impact nicotine exposure.
methodsThis review focuses on factors which may impact nicotine exposure by changing e-cigarette use behavior, puff topography, altering the nicotine yield (amount of nicotine exiting the e-cigarette mouth piece including nicotine exhaled as vapor) or more directly by altering nicotine absorption and bioavailability.
resultsTopics reviewed include e-liquid components or characteristics including flavor additives (e.g., menthol), base e-liquid ingredients (propylene glycol, vegetable glycerin), components commonly used to dissolve flavorants (e.g., ethanol), and resulting properties of the e-liquid (e.g., pH), e-cigarette device characteristics (e.g., wattage, temperature, model) and user behavior (e.g., puff topography) which may impact nicotine exposure.
conclusionE-liquid characteristics and components, e-cigarette hardware and settings, and user behavior can all contribute substantially to nicotine exposure from e-cigarettes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.