ReviewCurrent neuropharmacology2018
Blood Brain Barrier and Alzheimer's Disease: Similarity and Dissimilarity of Molecular Alerts.
Review in Current neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
- The validation of predictive potential via the system of self-consistent models: the simulation of blood-brain barrier permeation of organic compounds.Journal of molecular modeling · 2023Article
- Pesticides, cosmetics, drugs: identical and opposite influences of various molecular features as measures of endpoints similarity and dissimilarity.Molecular diversity · 2021Article
- Mechanisms of Blood-Brain Barrier Dysfunction in Traumatic Brain Injury.International journal of molecular sciences · 2020Review
- QSPR/QSAR: State-of-Art, Weirdness, the Future.Molecules (Basel, Switzerland) · 2020Review
- Intravenously Injected Mesenchymal Stem Cells Penetrate the Brain and Treat Inflammation-Induced Brain Damage and Memory Impairment in Mice.Frontiers in pharmacology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood brain barrier and Alzheimer's disease are interrelated. This interrelation is detected by physicochemical methods, pharmacological and electrophysiological analyses. Nature of the phenomenon is extremely complex. The description of this interrelation in mathematical terms is a very important task.
objectiveThe systematization of facts, which are described in the literature and related to interaction between processes, which influence Alzheimer's disease and blood brain barrier is the subject of this work. In addition, establishing of correlations between molecular features and endpoints, which are related to the treatment of Alzheimer's disease and blood brain barrier using the CORAL software are subjects of this work.
methodsThe information on logically structured analysis is available in the literature and building up quantitative structure - activity relationships (QSARs) by the Monte Carlo method has been used to solve the task of systematization of facts related to the "treatment of Alzheimer's disease vs. blood brain barrier".
resultsComparison of agreements and disagreements of the available published papers together with the statistical quality of built up QSARs are results of this work.
conclusionThe facts from published papers and technical details of QSAR built up in this study give possibility to formulate the following rules: (i) there are molecular alerts, which are promoters to increase blood brain barrier and therapeutic activity of anti-Alzheimer disease agents; (ii) there are molecular alerts, which contradict each other.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.