ArticleImmunity2017
Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4
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In one paragraph
Article in Immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 1 pooled it
11.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
134 citing papers in PubMed, 1 synthesis or guideline pooled it, 181 citations in OpenAlex.
- Transcriptome profiles of latently- and reactivated HIV-1 infected primary CD4Frontiers in immunology · 2022Pooled it
- Therapeutic HIV-1 Tat vaccination promotes durable immune reconstitution and reservoir reduction in ART-treated adults with clade C infection: a 12-year follow-up study.Frontiers in immunology · 2026Trial
- X4-Tropic Latent HIV-1 Is Enriched in Peripheral Follicular Helper T Cells and Is Correlated with Disease Progression.Journal of virology · 2020Trial
- Continued Decay of HIV Proviral DNA Upon Vaccination With HIV-1 Tat of Subjects on Long-Term ART: An 8-Year Follow-Up Study.Frontiers in immunology · 2019Trial
- Article
- HIV-1 infection does not confer intrinsic resistance to cell death induced by cytotoxic T lymphocytes.bioRxiv : the preprint server for biology · 2026Article
- HIV-producing resting T cells monopolize virus production, associated PANoptosis, and persistence in lymphoid tissue.bioRxiv : the preprint server for biology · 2026Article
- Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect.The Journal of experimental medicine · 2026Article
- RhCMV expands CCR5+ memory T cells and promotes SIV reservoir seeding in the gut mucosa.JCI insight · 2026Article
- Single-cell transcriptome profiling reveals immunological fitness of HIV long-term non-progressors.Journal of virology · 2025Article
- HIV reservoirs in lymphomagenesis: hidden driver in the era of viral suppression?Microbiology and molecular biology reviews : MMBR · 2025Review
- A decreased proportion of naïve MAIT cells is associated with the incomplete immune reconstitution in antiretroviral therapy-treated HIV-1 patients.Virologica Sinica · 2025Article
- Limitations and use of the Morpheus-V5 dual reporter virus in assessing interventions that target HIV latency.Journal of virological methods · 2025Article
- Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence.Immunity · 2025Article
- HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency.Nature microbiology · 2025Article
- HIV-induced T cell quiescence and the origins of viral latency.Nature immunology · 2025Article
- BACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4Cell reports. Medicine · 2025Article
- Using single cell technologies to understand HIV latency models.Current opinion in HIV and AIDS · 2025Review
- PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription.Nature communications · 2025Article
- Review
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 3 countries.
Liang ShanDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Kai DengDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.
Hongbo GaoInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.
Sifei XingDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Adam A CapoferriDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Christine M DurandDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
S Alireza RabiDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Gregory M LairdDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Michelle KimDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Nina N HosmaneDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Hung-Chih YangNational Taiwan University Hospital, Taipei 100, Taiwan.
Hao ZhangDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Joseph B MargolickDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Linghua LiDepartment of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510060, China.
Weiping CaiDepartment of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510060, China.
Ruian KeDepartment of Mathematics, North Carolina State University, Raleigh, NC 27695, USA.
Richard A FlavellDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
Janet D SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Robert F SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: rsiliciano@jhmi.edu.
Johns Hopkins University · USGuangzhou Eighth People's Hospital · CNHoward Hughes Medical Institute · USNational Taiwan University Hospital · TWNorth Carolina State University · USSun Yat-sen University · CN
Funding
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2MDelaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9MFirst-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5MCombined Immunologic Approaches to Cure HIV-1UM1AI126603 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H., MELLORS, JOHN W · 2016 to 2020
$23.6MTraining Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7MDeveloping humanized mouse models for the study of HIV-1 latency and viral eradicationK99AI125065 · NIAID · YALE UNIVERSITY · PI SHAN, LIANG · 2016 to 2016
$133kHoward Hughes Medical InstituteNIAID NIH HHS K99 AI125065NIAID NIH HHS P30 AI094189NIAID NIH HHS UM1 AI126603NIAID NIH HHS UM1 AI126611NIAID NIH HHS UM1 AI126620NIGMS NIH HHS T32 GM007309NIGMS NIH HHS T32 GM008752
Abstract
The latent reservoir for HIV-1 in resting memory CD4
Indexed as
Transcription, GeneticCD4-Positive T-LymphocytesCells, CulturedCellular ReprogrammingCytokinesFemaleFlow CytometryGene Expression ProfilingHIV-1Host-Pathogen InteractionsHumansImmunologic MemoryLymphocyte ActivationMaleReverse Transcriptase Polymerase Chain ReactionT-Lymphocytes, CytotoxicCytokines
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.