A RHIM with a View: FLYing with Functional Amyloids.

Sunny Shin, Sara Cherry

Abstract readComment

In one paragraph

Article in Immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Targeting necroptosis: a promising avenue for respiratory disease treatment.Cell communication and signaling : CCS · 2024
Review

4 · The record

Corrections and comments

Comment on
Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling.2017

5 · Who and what money

Authors and funding

2 authors.

Sunny ShinDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Sara CherryDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: cherrys@pennmedicine.upenn.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recognition of bacterial peptidoglycan by the Drosophila IMD pathway triggers NF-κB activation and an associated immune response. In this issue of Immunity, Kleino et al. (2017) show that proteins in the IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammalian RIPK proteins. Amyloid formation can be negatively regulated, suggesting that it presents a regulatory point in multiple biological processes.

Indexed as

Biological PhenomenaDrosophila ProteinsAnimalsDrosophilaNF-kappa BPeptidoglycanDrosophila ProteinsNF-kappa BPeptidoglycan

Identifiers

PMID29045890

DOI10.1016/j.immuni.2017.10.001

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.