Evidence map›Paper›PMID 29045880›Full record

ArticleBiophysical journal2017

A Model for Link Pruning to Establish Correctly Polarized and Oriented Tip Links in Hair Bundles.

Nathan Tompkins, Kateri J Spinelli, Dongseok Choi, Peter G Barr-Gillespie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nathan TompkinsOregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon.
Kateri J SpinelliOregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon.
Dongseok ChoiSchool of Public Health, Oregon Health and Science University, Portland, Oregon; Graduate School of Dentistry, Kyung Hee University, Seoul, South Korea.
Peter G Barr-GillespieOregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon. Electronic address: gillespp@ohsu.edu.

Funding

Hair-Bundle ProteinsR01DC002368 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Peter Gordon Barr-Gillespie · 1994 to 2026
$11.3M
NIDCD NIH HHS R01 DC002368
6 · The paper itself

Abstract

Tip links are thought to gate the mechanically sensitive transduction channels of hair cells, but how they form during development and regeneration remains mysterious. In particular, it is unclear how tip links are strung between stereocilia so that they are oriented parallel to a single axis; why their polarity is uniform despite their constituent molecules' intrinsic asymmetry; and why only a single tip link is present at each tip-link position. We present here a series of simple rules that reasonably explain why these phenomena occur. In particular, our model relies on each of the two ends of the tip link having distinct Ca

Indexed as

Computer SimulationModels, BiologicalAnimalsCalciumChelating AgentsChickensEgtazic AcidEpitheliumHair Cells, AuditoryMicroscopy, Electron, ScanningNeuromuscular Nondepolarizing AgentsStereociliaStochastic ProcessesTissue Culture TechniquesTubocurarine1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acidCalciumChelating AgentsEgtazic AcidNeuromuscular Nondepolarizing AgentsTubocurarine

Identifiers

PMID29045880
PMCPMC5647544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.