ArticleCell reports2017
Heterotopic Transplantations Reveal Environmental Influences on Interneuron Diversity and Maturation.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Decoding Brain Development and Function Through GABAergic Inhibitory Neurons.The European journal of neuroscience · 2026Review
- Impact of Prenatal Alcohol Exposure on Cerebral Cortex Development.Advances in experimental medicine and biology · 2026Review
- Mature interneuron subtypes arise from distinct spatial and temporal subdomains within the caudal ganglionic eminence.bioRxiv : the preprint server for biology · 2025Article
- Fate plasticity of interneuron specification.iScience · 2025Article
- Medial ganglionic eminence transplantation restores inhibition after central visual system brain injury.PNAS nexus · 2025Article
- Host brain environmental influences on transplanted medial ganglionic eminence progenitors.Scientific reports · 2024Article
- Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles.Frontiers in cellular neuroscience · 2024Article
- In vivo development and single-cell transcriptome profiling of human brain organoids.Cell proliferation · 2022Article
- Origin, Development, and Synaptogenesis of Cortical Interneurons.Frontiers in neuroscience · 2022Review
- The behavior and functions of embryonic microglia.Anatomical science international · 2022Review
- Cell-type specific transcriptomic signatures of neocortical circuit organization and their relevance to autism.Frontiers in neural circuits · 2022Article
- From Progenitors to Progeny: Shaping Striatal Circuit Development and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- The organization and development of cortical interneuron presynaptic circuits are area specific.Cell reports · 2021Article
- The Epigenome in Neurodevelopmental Disorders.Frontiers in neuroscience · 2021Review
- Interneuron Types as Attractors and Controllers.Annual review of neuroscience · 2020Review
- Pluripotent stem cell derived inhibitory interneurons - principles and applications in health and disease.Neural regeneration research · 2020Article
- Circuit development in the master clock network of mammals.The European journal of neuroscience · 2020Review
- Article
- Human Pluripotent Stem Cell-Derived Striatal Interneurons: Differentiation and Maturation In Vitro and in the Rat Brain.Stem cell reports · 2019Article
- Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains.Journal of visualized experiments : JoVE · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
During embryogenesis, neural progenitors in the ganglionic eminences give rise to diverse GABAergic interneuron subtypes that populate all forebrain regions. The extent to which these cells are genetically predefined or determined by postmigratory environmental cues remains unknown. To address this question, we performed homo- and heterotopic transplantation of early postnatal MGE-derived cortical and hippocampal interneurons. Grafted cells migrated, and displayed neurochemical, electrophysiological, morphological, and neurochemical profiles similar to endogenous interneurons. Our results indicate that the host environment regulates the proportion of interneuron classes in the brain region. However, some specific interneuron subtypes retain characteristics representative of their donor brain regions.
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Registered trials
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