ArticleCell reports2017
A Cell Migration Tracking Tool Supports Coupling of Tissue Rotation to Elongation.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Analyzing cell migration history in vivo using fluorescent fibrillar collagen trails.Communications biology · 2026Article
- Basement membrane patterning by spatial deployment of a secretion-regulating protease.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The WIRS motifs in Fat2 are required for Drosophila egg chamber rotation but not for elongation.Development (Cambridge, England) · 2025Article
- Bellymount-pulsed tracking: a novel approach for real-time in vivo imaging of Drosophila abdominal tissues.G3 (Bethesda, Md.) · 2025Article
- Basement membrane diversification relies on two competitive secretory routes defined by Rab10 and Rab8 and modulated by dystrophin and the exocyst complex.PLoS genetics · 2024Article
- Finishing the egg.Genetics · 2024Article
- Methods and computational tools to study eukaryotic cell migrationFrontiers in cell and developmental biology · 2024Review
- Chondroitin sulfate is required for follicle epithelial integrity and organ shape maintenance in Drosophila.Development (Cambridge, England) · 2023Article
- Peripodial adherens junctions regulate Ajuba-Yorkie signaling to preserve fly eye morphology.Biology open · 2023Article
- Fat2 polarizes the WAVE complex ineLife · 2022Article
- Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo.Development (Cambridge, England) · 2022Article
- Cellular and Supracellular Planar Polarity: A Multiscale Cue to Elongate theFrontiers in cell and developmental biology · 2021Review
- Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation.Development (Cambridge, England) · 2020Article
- Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation.Nature communications · 2019Article
- Planar-Polarized Semaphorin-5c and Plexin A Promote the Collective Migration of Epithelial Cells in Drosophila.Current biology : CB · 2019Article
- Basement membrane mechanics shape development: Lessons from the fly.Matrix biology : journal of the International Society for Matrix Biology · 2019Review
- Three-dimensional microscopy and image analysis methodology for mapping and quantification of nuclear positions in tissues with approximate cylindrical geometry.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cell migration is indispensable to morphogenesis and homeostasis. Live imaging allows mechanistic insights, but long-term observation can alter normal biology, and tools to track movements in vivo without perturbation are lacking. We develop here a tool called M-TRAIL (matrix-labeling technique for real-time and inferred location), which reveals migration histories in fixed tissues. Using clones that overexpress GFP-tagged extracellular matrix (ECM) components, motility trajectories are mapped based on durable traces deposited onto basement membrane. We applied M-TRAIL to Drosophila follicle rotation, comparing in vivo and ex vivo migratory dynamics. The rate, trajectory, and cessation of rotation in wild-type (WT) follicles measured in vivo and ex vivo were identical, as was rotation failure in fat2 mutants. However, follicles carrying intracellularly truncated Fat2, previously reported to lack rotation ex vivo, in fact rotate in vivo at a reduced speed, thus revalidating the hypothesis that rotation is required for tissue elongation. The M-TRAIL approach could be applied to track and quantitate in vivo cell motility in other tissues and organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.